Special Issue "Male Reproduction: Regulation, Differentiation and Epigenetics"
Deadline for manuscript submissions: closed (20 October 2021).
Interests: testis; spermatogenesis; male fertility; endocrine disruptors; HPG axis
Interests: testis; spermatogenesis; male fertility; endocrine disruptors; cytoskeleton; blood–testis barrier
Infertility is a global problem affecting 15%–20% of couples. This condition, equally distributed between males and females, can have several causes, including genetic or epigenetic defects, hypogonadism, as well as environmental and pathological issues. In particular, good-quality spermatozoa with normal morphology and motility are essential for male fertility. Sperm production occurs in the testis and involves the gradual differentiation of germ cells, which changes their size, structural organization, and composition into mature spermatozoa within the extensive seminiferous epithelium. The whole process is harmonized not only by a cell type- and stage-specific induction or repression of the expression of specific genes, but it is also regulated by gonadotropins, steroid hormones, and a complex network of autocrine and paracrine factors. All of the phases leading to the production of mature spermatozoa (spermatogenesis, spermiohistogenesis, and their hormonal control) can be affected by environmental pollutants such as endocrine disruptors, drugs, and micro- and nanoplastics. It must be highlighted that all these factors may contribute not only to affect the sperm quality, but also to produce epigenetic changes that are hereditable and may influence the development and health of offspring. This Special Issue, in addition to expanding the current knowledge on this topic, may be a useful guide for the researchers interested in the field of male infertility.
New research, in vitro and/or in vivo studies in vertebrates, as well as review and clinical studies are all welcome for consideration.
Prof. Sergio Minucci
Dr. Massimo Venditti
Manuscript Submission Information
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- Male fertility
- HPG axis
- Blood–testis barrier
- Endocrine Disrupters
- Environmental factors
- Male germ cell development
- Male germ cell differentiation