Next Article in Journal
Evaluation of RT-qPCR and Loop-Mediated Isothermal Amplification (LAMP) Assays for the Detection of SARS-CoV-2 in Argentina
Next Article in Special Issue
Pediatric and Adolescent Oncofertility in Male Patients—From Alpha to Omega
Previous Article in Journal
The Maze Pathway of Coevolution: A Critical Review over the Leishmania and Its Endosymbiotic History
Review

LINCking the Nuclear Envelope to Sperm Architecture

1
Dipartimento di Medicina Sperimentale, Università degli Studi della Campania L. Vanvitelli, Via Costantinopoli 16, 80138 Napoli, Italy
2
PRC, CNRS, IFCE, INRAE, University of Tours, 37380 Nouzilly, France
*
Author to whom correspondence should be addressed.
Academic Editor: Konstantin Khrapko
Genes 2021, 12(5), 658; https://doi.org/10.3390/genes12050658
Received: 24 March 2021 / Revised: 13 April 2021 / Accepted: 24 April 2021 / Published: 27 April 2021
(This article belongs to the Special Issue Male Reproduction: Regulation, Differentiation and Epigenetics)
Nuclear architecture undergoes an extensive remodeling during spermatogenesis, especially at levels of spermatocytes (SPC) and spermatids (SPT). Interestingly, typical events of spermiogenesis, such as nuclear elongation, acrosome biogenesis, and flagellum formation, need a functional cooperation between proteins of the nuclear envelope and acroplaxome/manchette structures. In addition, nuclear envelope plays a key role in chromosome distribution. In this scenario, special attention has been focused on the LINC (linker of nucleoskeleton and cytoskeleton) complex, a nuclear envelope-bridge structure involved in the connection of the nucleoskeleton to the cytoskeleton, governing mechanotransduction. It includes two integral proteins: KASH- and SUN-domain proteins, on the outer (ONM) and inner (INM) nuclear membrane, respectively. The LINC complex is involved in several functions fundamental to the correct development of sperm cells such as head formation and head to tail connection, and, therefore, it seems to be important in determining male fertility. This review provides a global overview of the main LINC complex components, with a special attention to their subcellular localization in sperm cells, their roles in the regulation of sperm morphological maturation, and, lastly, LINC complex alterations associated to male infertility. View Full-Text
Keywords: LINC complex; SUN; KASH; actin; spermatozoa; male fertility LINC complex; SUN; KASH; actin; spermatozoa; male fertility
Show Figures

Figure 1

MDPI and ACS Style

Manfrevola, F.; Guillou, F.; Fasano, S.; Pierantoni, R.; Chianese, R. LINCking the Nuclear Envelope to Sperm Architecture. Genes 2021, 12, 658. https://doi.org/10.3390/genes12050658

AMA Style

Manfrevola F, Guillou F, Fasano S, Pierantoni R, Chianese R. LINCking the Nuclear Envelope to Sperm Architecture. Genes. 2021; 12(5):658. https://doi.org/10.3390/genes12050658

Chicago/Turabian Style

Manfrevola, Francesco, Florian Guillou, Silvia Fasano, Riccardo Pierantoni, and Rosanna Chianese. 2021. "LINCking the Nuclear Envelope to Sperm Architecture" Genes 12, no. 5: 658. https://doi.org/10.3390/genes12050658

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop