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LINCking the Nuclear Envelope to Sperm Architecture

Dipartimento di Medicina Sperimentale, Università degli Studi della Campania L. Vanvitelli, Via Costantinopoli 16, 80138 Napoli, Italy
PRC, CNRS, IFCE, INRAE, University of Tours, 37380 Nouzilly, France
Author to whom correspondence should be addressed.
Academic Editor: Konstantin Khrapko
Genes 2021, 12(5), 658;
Received: 24 March 2021 / Revised: 13 April 2021 / Accepted: 24 April 2021 / Published: 27 April 2021
(This article belongs to the Special Issue Male Reproduction: Regulation, Differentiation and Epigenetics)
Nuclear architecture undergoes an extensive remodeling during spermatogenesis, especially at levels of spermatocytes (SPC) and spermatids (SPT). Interestingly, typical events of spermiogenesis, such as nuclear elongation, acrosome biogenesis, and flagellum formation, need a functional cooperation between proteins of the nuclear envelope and acroplaxome/manchette structures. In addition, nuclear envelope plays a key role in chromosome distribution. In this scenario, special attention has been focused on the LINC (linker of nucleoskeleton and cytoskeleton) complex, a nuclear envelope-bridge structure involved in the connection of the nucleoskeleton to the cytoskeleton, governing mechanotransduction. It includes two integral proteins: KASH- and SUN-domain proteins, on the outer (ONM) and inner (INM) nuclear membrane, respectively. The LINC complex is involved in several functions fundamental to the correct development of sperm cells such as head formation and head to tail connection, and, therefore, it seems to be important in determining male fertility. This review provides a global overview of the main LINC complex components, with a special attention to their subcellular localization in sperm cells, their roles in the regulation of sperm morphological maturation, and, lastly, LINC complex alterations associated to male infertility. View Full-Text
Keywords: LINC complex; SUN; KASH; actin; spermatozoa; male fertility LINC complex; SUN; KASH; actin; spermatozoa; male fertility
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MDPI and ACS Style

Manfrevola, F.; Guillou, F.; Fasano, S.; Pierantoni, R.; Chianese, R. LINCking the Nuclear Envelope to Sperm Architecture. Genes 2021, 12, 658.

AMA Style

Manfrevola F, Guillou F, Fasano S, Pierantoni R, Chianese R. LINCking the Nuclear Envelope to Sperm Architecture. Genes. 2021; 12(5):658.

Chicago/Turabian Style

Manfrevola, Francesco, Florian Guillou, Silvia Fasano, Riccardo Pierantoni, and Rosanna Chianese. 2021. "LINCking the Nuclear Envelope to Sperm Architecture" Genes 12, no. 5: 658.

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