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Special Issue "Genetics and Genomics of Malaria Parasites"
Deadline for manuscript submissions: closed (30 June 2019).
Prof. Liwang Cui E-Mail
University of South Florida.
Interests: malaria; developmental biology; epigenetics; translation regulation; drug resistance; functional genomics
In 2016, the World Health Organization estimated that 3.4 billion people were at risk of malaria, with approximately 80% of malaria cases and 90% of deaths occurring in sub-Saharan Africa. In non-human primates, approximately 25 malaria parasite species have been described. Among them, six species including Plasmodium falciparum, P. vivax. P. malariae, P. ovale, P. knowlesi, and P. simium are known to infect humans, causing malaria. Plasmodium falciparum is responsible for hundreds of millions of cases of malaria, and kills about half a million annually. While P. falciparum causes most malaria mortality, P. vivax can also cause severe disease and, rarely, death.
The genetics and genomics of malaria parasites reveal evolutionary processes/mechanisms and inheritance patterns. Genetic information helps track the movement of infectious pathogens as well as the response to malaria interventions over time. The advent and accessibility of high-throughput sequencing technologies and bioinformatic tools in the last decade provides remarkable insights into the global genetic structure, genomic composition, and recombination rates, as well as genetic variants associated with antimalarial drug resistance of Plasmodium. Global malaria elimination programs focus primarily on P. falciparum. Nevertheless, non-P. falciparum malaria still presents a major challenge for malaria elimination. Recent research efforts and control programs have drawn resources to P. vivax malaria. In contrast, other Plasmodium species receive little attention, and malaria caused by these organisms is among the most neglected tropical diseases.
This Special Issue will cover the genetic and/or genomic features of the various malaria parasite species in the context of disease epidemiology, evolution, functions of genes or gene products, and host–pathogen interactions. We cordially invite researchers working in these areas to contribute to this Special Issue with original research or reviews.
Prof. Eugenia Lo
Prof. Liwang Cui
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Functional genomics
- Population genomics
- Antimalarial drug resistance
- Gene functions and products
- Host-pathogen interactions
- Malaria epidemiology