Genomics of Mood Disorders

Dear Colleagues,

Mental disorders such as depression (MDD) and bipolar disorder (BD) have high heritabilities, indicating a genetic component to their etiology. The application of new technologies as genome-wide association studies (GWAS) and next-generation sequencing (NGS) technologies to large population-based sample has resulted in hundreds of new genetic findings for these disorders. This is uncovering the role of common and rare genetic variants in the etiology of these disorders and the contribution of environmental events in triggering the development of mood disorders. From a clinical point of view mood disoders are characterized by mortality due to suicide, significant disability, different response to treatments and heterogeneity of outcome. Therefore, despite the genetic underpinning, it becomes important to explore, also through the use of endophenotypes, the different developmental trajectories of these disoders.

The Special Issue of Genes, “Genomics of Mood Disorders”, will bring together several reviews and original articles that will explore genetic background, environmental associated epigenetic changes, gene–environmental interactions in mood disoders, and give a broad overview of new advances in the field, including pathophysiological mechanisms, pharmacogenetics, diagnostic biomarkers, endophenotypic approach providing novel insights into the biology of these disorders.

Dr. Sarah Tosato
Dr. Chiara Bonetto
Guest Editors

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