Special Issue "The Epitranscriptome in Human Disease"
Deadline for manuscript submissions: closed (1 November 2018)
Genetic information is transcribed from DNA to RNA before it is being used during translation or as regulatory RNAs. Consequently, RNA was believed to be a mere copy of the information stored in DNA. However, recent work has shown that RNA can be chemically modified by processes commonly referred to as RNA modification and RNA editing.
Both, the bases and ribose moieties of RNA can be methylated, while the bases can be modified in around hundred different ways. The chemical alterations can change the information stored in RNA and lead to recoding, but can also change the fate of RNAs by binding to different factors. Lastly, some modifications are reversible and can be removed. The circle of nucleotide modification (writing), recognition by interactors (reading), and removal of the modification (erasing) has led to the term “Epitranscriptome” by analogy to the well studied modifications of the Epigenome. Today it is clear that epitranscriptomic modifications can be altered as a response to changing conditions. It has also become obvious that failure to write, read, or erase epitranscriptomic modifications can be the cause of severe diseases and developmental defects.
This special issue provides an overview on the impact and function of the Epitranscriptome during normal development and disease. The articles describe the proper function of writers, readers and erasers and the homeostasis and consequences of epitranscriptomic modifications. Several articles in this issue are sponsored by the European EPITRAN COST action CA16120 that aims at fostering epitranscriptome research in Europe.
Prof. Dr. Michael Jantsch
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- RNA modification
- RNA editing
- neuromuscular disease
- RNA turnover