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RNA Editors, Cofactors, and mRNA Targets: An Overview of the C-to-U RNA Editing Machinery and Its Implication in Human Disease

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Division of Immune Diversity, Program in Cancer Immunology, German Cancer Research Centre, 69120 Heidelberg, Germany
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Division of Biosciences, Uni Heidelberg, 69120 Heidelberg, Germany
*
Authors to whom correspondence should be addressed.
Genes 2019, 10(1), 13; https://doi.org/10.3390/genes10010013
Received: 1 November 2018 / Revised: 10 December 2018 / Accepted: 20 December 2018 / Published: 27 December 2018
(This article belongs to the Special Issue The Epitranscriptome in Human Disease)
One of the most prevalent epitranscriptomic modifications is RNA editing. In higher eukaryotes, RNA editing is catalyzed by one of two classes of deaminases: ADAR family enzymes that catalyze A-to-I (read as G) editing, and AID/APOBEC family enzymes that catalyze C-to-U. ADAR-catalyzed deamination has been studied extensively. Here we focus on AID/APOBEC-catalyzed editing, and review the emergent knowledge regarding C-to-U editing consequences in the context of human disease. View Full-Text
Keywords: RNA editing; epitranscriptome; neurological disorders; AID/APOBEC RNA editing; epitranscriptome; neurological disorders; AID/APOBEC
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MDPI and ACS Style

Lerner, T.; Papavasiliou, F.N.; Pecori, R. RNA Editors, Cofactors, and mRNA Targets: An Overview of the C-to-U RNA Editing Machinery and Its Implication in Human Disease. Genes 2019, 10, 13.

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