System Metabolic Engineering
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Microbial Genetics and Genomics".
Deadline for manuscript submissions: closed (25 January 2022) | Viewed by 5394
Special Issue Editor
Interests: metabolic engineering; novel metabolic pathway; synthetic biology; evolutionary engineering
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
One of the current global challenges is tackling climate change. To address the latter, one strategy is to develop a biobased economy to replace the declining and polluting fossil-based economy. Microbial cell factories play a key role in producing added-value compounds from sustainable feedstocks such as non-food biomass or atmospheric CO2. Since the beginning of the 1990s, microorganisms have gained more and more attention for use as a chassis, as they are able to naturally produce many different metabolites of interest. However, the efficiency of the natural production is rather low and falls short of the expected industrial performance in three key indices: yield, titer and productivity. Metabolic engineering pushed by the development of various synthetic biology tools is an essential pillar for generating synthetic, industrially competitive microorganisms.
This Special Issue will focus on recent advances in system metabolic engineering, including i) system biology for an accurate analysis of microbial metabolism, ii) the creation of novel or non-natural metabolic pathways, iii) the fine tuning of gene expression, and iv) genome editing to finally create highly efficient, engineered, tailormade microorganisms. Successful examples of metabolic engineering strategies using synthetic biology tools could be also described.
Prof. Dr. Isabelle Meynial-Salles
Guest Editor
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Keywords
- System biology
- Synthetic biology
- Evolutionary engineering
- Novel (non-natural) metabolic pathway
- Metabolic engineering
- Genome-scale metabolic model
- Genome editing
- Biobased economy
- Sustainable feedstocks
- CO2 assimilation
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