System Metabolic Engineering

Dear Colleagues,

One of the current global challenges is tackling climate change. To address the latter, one strategy is to develop a biobased economy to replace the declining and polluting fossil-based economy. Microbial cell factories play a key role in producing added-value compounds from sustainable feedstocks such as non-food biomass or atmospheric CO₂. Since the beginning of the 1990s, microorganisms have gained more and more attention for use as a chassis, as they are able to naturally produce many different metabolites of interest. However, the efficiency of the natural production is rather low and falls short of the expected industrial performance in three key indices: yield, titer and productivity. Metabolic engineering pushed by the development of various synthetic biology tools is an essential pillar for generating synthetic, industrially competitive microorganisms.

This Special Issue will focus on recent advances in system metabolic engineering, including i) system biology for an accurate analysis of microbial metabolism, ii) the creation of novel or non-natural metabolic pathways, iii) the fine tuning of gene expression, and iv) genome editing to finally create highly efficient, engineered, tailormade microorganisms. Successful examples of metabolic engineering strategies using synthetic biology tools could be also described.

Prof. Dr. Isabelle Meynial-Salles
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.