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Special Issue "Microbial Metabolic Engineering"
Deadline for manuscript submissions: closed (28 February 2018).
Due to climate change, there is a growing interest in producing chemicals, materials and more generally value added compounds by microbial cell factories from renewable non-food biomass to substitute the actual pollutant petrochemical pathways. Metabolic engineering is therefore a pillar of the Bioeconomy which will represent a strong and growing market over the next years and compete effectively and in a more sustainable way to the growing use of fossil resources.
Indeed, microorganisms have a strong potential as there are able to naturally produce lots of different metabolites of interest. However the production of compounds from natural or transformed microorganisms may be low and genetic modifications are often requested to create microorganisms in which the yield of production can effectively be competitive to the classical production of molecules from chemical engineering. This is why, since the beginning of the 1990s, metabolic engineering strategies have focused on improving, by all ways possible, the metabolic performance to obtain industrially-tailored microorganisms. More recently, the fast development of synthetic biology tools pushed the microbial metabolic engineering in a new era opening the opportunity to introduce, through rational approaches, non-natural metabolic pathways, and finally produce molecules that are completely absent in Nature’s repertoire.
This special issue will focus on the recent advances and breakthroughs issued from the Synthetic and Systems Biology community and aiming at improving not only the performance of engineered or natural producing microorganisms but also the predictability of such genetic manipulations. We will notably focus on the powerful tools for an accurate analysis of the microbial metabolism, for fast and precise genome engineering, to design via computation artificial biological molecules or pathway, for the design and creation of tailored-made non-natural enzymes and synthetic metabolic pathways and to finally develop highly efficient engineered microorganisms. Successful examples of metabolic engineering strategies using synthetic biology tools will also be described.
Prof. Dr. Isabelle Meynial-Salles
Prof. Dr. Gilles Truan
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Metabolic Engineering
- Synthetic Biology tools
- Genome Scale Model
- Genome Engineering
- Synthetic Metabolic Pathways