Plant Metabolic Engineering of High Value Bioactive Products
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Plant Genetics and Genomics".
Deadline for manuscript submissions: closed (31 October 2018) | Viewed by 35591
Special Issue Editors
Interests: plant synthetic biology; specialized metabolites; cyanogenic glucosides; diterpenoids; phenylpropanoids; biosynthetic complexes; metabolons
Interests: specialized metabolism; metabolic channeling; dynamic metabolons; flavonoids; cyanogenic glucosides
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Specialized metabolites in plants play a key role in the ability of plants to adapt to biotic and abiotic environmental stresses, and constitute a treasure trove of small molecules that are used by humans, e.g., to improve health and as condiments, pigments and low calorie natural sweeteners in foods. They are an integrated part of daily life. The approaches of synthetic biology may be used to widen the access to these valuable constituents by offering more direct and sustainable production systems. Development of contained production in green heterologous hosts like green algae, cyanobacteria and mosses requires detailed knowledge of the genes and enzymes involved in their formation, understanding of the organization of the enzymes in efficient metabolic modules to configure metabolic highways and development of technologies for environmental benign of isolation of the product formed. Monooxygenases and associated electron donating redox proteins are some of the key enzymes involved in obtaining the diversity of specialized metabolites in plants. Plants and other photosynthetic organisms have the unique ability to convert solar energy into reducing equivalents and to utilize carbon dioxide from the air as their sole carbon source. Improved photosynthesis and direct coupling of the reducing power of photosystem I to enzyme modules catalyzing formation of specialized metabolites would facilitate channeling of sunlight towards production of high value chemically complex compounds. The modular nature of the biosynthetic pathways provides an option to use a combinatorial approach to direct and optimize the production of known and new-to-nature compounds. Hence, synthetic biology is emerging as a novel approach to design and engineer biological modules with desired functional properties.
We cordially invite researchers working actively within these fields to submit their original research or review manuscripts to this Special Issue on “Plant Metabolic Engineering of High Value Bioactive Products”.
Prof. Birger Lindberg Møller
Dr. Tomas Laursen
Guest Editors
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Keywords
- Synthetic biology
- Specialized metabolites
- Biosynthetic modules
- Isolation of enzyme complexes
- Metabolic engineering
- Metabolic highways
- Pathway flux analyses
- Storage and possible involvement of biomolecular condensates
- Photosynthesis
- Light harvesting complexes
- Reaction centers
- Environmental benign isolation procedures
- Plants
- Cyanobacteria
- Algae
- Moss
- Cytochromes P450
- Oxidoreductases
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