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Special Issue "DNA Methylation in Health and Diseases"
Deadline for manuscript submissions: 1 November 2019.
The completion of the human genome project produced a comprehensive list of all genes necessary to build a human organism. However, years of extensive research have demonstrated that the situation is far more complex than a simple list of genes. There is an additional system encoding spatio-temporal information that cells use to determine when and where a particular gene will be expressed during development. This information is overlaid upon the DNA in the form of epigenetic marks, which are heritable during cell division but do not involve changes in the DNA sequence. One of the best characterized epigenetic modification of DNA in mammalian cells is the methylation of cytosines belonging to CpG doublets.
Here we review the impact of the studies on DNA methylation, the “primadonna” in the epigenetic scenario, on the understanding of basic processes and pathological conditions that bring the so-called Chromatin Diseases.
This Special Issue will thus be subdivided into contributions focused on the role of DNA methylation in biological processes, such as imprinting, the establishment of pluripotency, the impact of nutrients in brain epigenetics, and the changes of DNA methylation during brain development. The study of the DNA methylation changes in the diagnosis of genetic diseases will be discussed.
Conversely, the alteration of DNA methylation in genetic diseases will be thoroughly discussed, including relatively rare diseases (e.g., FSHD syndrome) and more common diseases, such as unstable repeat disorders as well as renal and immune diseases. Pathologies such as ischemic stroke, and its association to epigenetic deregulation and DNA methylation, will be also discussed.
Finally, we will give attention to the alterations in components of DNA methylation machinery (either writers or readers), which give rise to diseases such as Rett syndrome, mutated in the transcriptional modulator MECP2 and ICF syndrome, and mutated in the DNA methyltransferase DNMT3B.
Prof. Dr. Maurizio D'Esposito
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- DNA methylation
- genome architecture
- genomic imprinting
- chromatin diseases
- mechanisms of diseases