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Pathogenesis of Ischemic Stroke: Role of Epigenetic Mechanisms

IRCCS Neuromed, Via Atinense, 18, 86077 Pozzilli IS, Italy
Department of Clinical and Molecular Medicine, School of Medicine and Psychology, Sapienza University of Rome, 00189 Rome, Italy
Author to whom correspondence should be addressed.
Genes 2020, 11(1), 89;
Received: 29 November 2019 / Revised: 29 December 2019 / Accepted: 9 January 2020 / Published: 13 January 2020
(This article belongs to the Special Issue DNA Methylation in Health and Diseases)
Epigenetics is the branch of molecular biology that studies modifications able to change gene expression without altering the DNA sequence. Epigenetic modulations include DNA methylation, histone modifications, and noncoding RNAs. These gene modifications are heritable and modifiable and can be triggered by lifestyle and nutritional factors. In recent years, epigenetic changes have been associated with the pathogenesis of several diseases such as diabetes, obesity, renal pathology, and different types of cancer. They have also been related with the pathogenesis of cardiovascular diseases including ischemic stroke. Importantly, since epigenetic modifications are reversible processes they could assist with the development of new therapeutic approaches for the treatment of human diseases. In the present review article, we aim to collect the most recent evidence concerning the impact of epigenetic modifications on the pathogenesis of ischemic stroke in both animal models and humans. View Full-Text
Keywords: ischemic stroke; epigenetic; DNA methylation; histone modification; miRNA; lncRNA ischemic stroke; epigenetic; DNA methylation; histone modification; miRNA; lncRNA
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MDPI and ACS Style

Stanzione, R.; Cotugno, M.; Bianchi, F.; Marchitti, S.; Forte, M.; Volpe, M.; Rubattu, S. Pathogenesis of Ischemic Stroke: Role of Epigenetic Mechanisms. Genes 2020, 11, 89.

AMA Style

Stanzione R, Cotugno M, Bianchi F, Marchitti S, Forte M, Volpe M, Rubattu S. Pathogenesis of Ischemic Stroke: Role of Epigenetic Mechanisms. Genes. 2020; 11(1):89.

Chicago/Turabian Style

Stanzione, Rosita, Maria Cotugno, Franca Bianchi, Simona Marchitti, Maurizio Forte, Massimo Volpe, and Speranza Rubattu. 2020. "Pathogenesis of Ischemic Stroke: Role of Epigenetic Mechanisms" Genes 11, no. 1: 89.

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