Genetics of Embryonic Organogenesis: From Cell Differentiation to Disease
A Special Issue of Genes (ISSN 2073-4425) belonging to the section "Human Genomics and Genetic Diseases".
Deadline for manuscript submissions: 20 May 2027 | Viewed by 37
Editors
Interests: human embryonic development; nephrogenesis; congenital anomalies of the kidney and urinary tract (CAKUT); developmental signaling pathways; renal pathology and tumor biology
Special Issues, Collections and Topics in MDPI journals
2. Center for Translational Research in Biomedicine, University of Split School of Medicine, Šoltanska 2A, 21000 Split, Croatia
Interests: developmental nephrology; embryonic organogenesis; quantitative multiplex immunofluorescence; transcriptomic data integration; renal fibrosis and tumor biology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Embryonic organogenesis transforms a small pool of progenitor cells into functionally distinct organs through tightly timed programs of proliferation, differentiation, migration and programmed cell death. When these programs are disturbed, the outcome is a congenital anomaly, and the same pathways are frequently reactivated later in life in fibrosis, degeneration and cancer. Classical embryology described these events morphologically; over the past two decades lineage tracing, conditional animal models, organoids, single-cell and spatial transcriptomics, and quantitative multiplex imaging of human fetal tissue have made it possible to resolve the genetic control of organ formation at cellular level. This Special Issue aims to connect gene expression during organogenesis with cell fate decisions and disease phenotypes across organ systems, with particular attention to the kidney and urinary tract, the heart, the placenta and the nervous system. We welcome original research articles, short communications and reviews on developmental signaling pathways, congenital malformations including CAKUT, animal and organoid models, single-cell and spatial omics, and on developmental programs that are reactivated in postnatal disease and tumor biology.
Prof. Dr. Katarina Vukojević
Dr. Nela Kelam
Guest Editors
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Keywords
- embryonic organogenesis
- cell differentiation
- developmental signaling pathways
- lineage specification
- nephrogenesis
- congenital anomalies of the kidney and urinary tract (CAKUT)
- congenital malformations
- single-cell and spatial transcriptomics
- organoids
- animal models of development
- immunohistochemistry and immunofluorescence
- developmental pathways in disease and cancer
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