Genetic and Genomic Abnormalities in Cancer

Dear Colleagues,

Background: Genetic and genomic alterations are at the basis of the mechanisms behind the somatic cell phenotype modification from normal to tumoral. Such DNA aberrations range from simple point mutations (resulting in coding gene misexpression) to chromosomal aberrations, considering alterations in the ploidy number and chromosome structure. The latter have a strong impact on oncogene and tumor suppressor gene transcription.

Aim and scope: The present Special Issue aims to collect the most interesting insights into the genetics and genomics of tumor cells in order to provide new evidence to identify new genetic biomarkers that can possibly be used in non-invasive diagnostic assays.

History: In recent decades, the development of next-generation sequencing technologies has revolutionized the perspectives of cancer research, leading to an exponential amplification of our knowledge on cancer genetics and genomics. This huge amount of information is now being refined via more sophisticated approaches (such as single-cell sequencing) and integrations with a number of disease features.

Cutting-Edge Research

• Identification of novel genetic mutations, fusion genes, chromosomal alterations, and copy number variations associated with a specific tumor type.
• Functional impact of genetic/genomic alterations on tumor onset and progression.
• Epigenetic alterations accompanying specific genetic/genomic alterations in cancer.
• Novel bioinformatics applied to next-generation sequencing approaches in cancer research. 
• Genetic/genomics alterations in the diagnosis (mainly in non-invasive approaches), prognosis, and treatment of cancer patients.
• Single-cell sequencing discoveries and bioinformatic tools in cancer research.

The kinds of papers that we are soliciting: We request researchers, clinicians, and experts in the fields of genetics and genomics to contribute research articles, reviews, and short communications on the Special Issue’s topic.

Dr. Clelia Tiziana Storlazzi
Dr. Doron Tolomeo
Dr. Giorgia Simonetti
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

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