Recent Advances on Hydrogels and Hydrogel Composites for 3D/4D Printing

A special issue of Gels (ISSN 2310-2861).

Deadline for manuscript submissions: closed (31 August 2022) | Viewed by 4112

Special Issue Editors

College of Materials Science and Engineering, Zhejiang University of Technology, Hangzhou 310014, China
Interests: tough hydrogels; 3D printing; soft electronics; biomaterials; biomedical applications
Special Issues, Collections and Topics in MDPI journals
College of Materials Science & Engineering, Taiyuan University of Technology, Taiyuan 030024, China
Interests: functional hydrogels; 3D printing; soft electronics; biomaterials

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Guest Editor
School of Materials Science and Engineering, Tiangong University, Tianjin 300387, China
Interests: tough hydrogel; soft materials; polymer physics

Special Issue Information

Dear Colleagues,

Three-dimensional printed hydrogels have attracted tremendous interest owning to their enormous potential in a wide range of engineering fields. Compared to traditional manufacturing technologies, 3D printing can process multiple hydrogels into delicate structures with versatile dimensions and desired functions, which could meet the requirements of customization for different applications, such as soft robotics, medical devices, or wearable electronics.

The objective of this Special Issue is to present recent advances in functional hydrogels, especially tough or functional hydrogels prepared using the 3D printing method. The general topic of interest is gel materials, including but not limited to the 3D printing of the hydrogels, gel-based biomaterials, gel-based actuators, gel-based electronics, etc.

In this Special Issue, both original research articles and reviews are welcome. We look forward to receiving your contributions.

Dr. Siyu Zheng
Dr. Fengbo Zhu
Dr. Yanjie Wang
Guest Editors

Manuscript Submission Information

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Keywords

  • 3D printing
  • Hydrogels
  • Biomaterials
  • Electronics
  • Soft robotics

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Published Papers (1 paper)

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Research

10 pages, 2837 KiB  
Article
PCL/Sodium-Alginate Based 3D-Printed Dual Drug Delivery System with Antibacterial Activity for Osteomyelitis Therapy
by Ji-Hyun Lee, Jung-Kyu Park, Kuk-Hui Son and Jin-Woo Lee
Gels 2022, 8(3), 163; https://doi.org/10.3390/gels8030163 - 5 Mar 2022
Cited by 21 | Viewed by 3478
Abstract
Chronic osteomyelitis is mostly caused by bacteria such as S. aureus, and is often treated with oral antibiotics or injections to suppress the bacteria. In severe cases, however, surgical treatment using antibiotic beads and metal supports may be required. In these surgeries, [...] Read more.
Chronic osteomyelitis is mostly caused by bacteria such as S. aureus, and is often treated with oral antibiotics or injections to suppress the bacteria. In severe cases, however, surgical treatment using antibiotic beads and metal supports may be required. In these surgeries, bacterial attachment to the metal may lead to biofilm formation and reduce antibiotics’ penetration to the bacteria. Reoperation must be performed to prevent bacterial inflammatory reactions and antibiotic resistance. Thus, in this study, we developed a dual-drug-releasing PCL/sodium-alginate-based 3D-printed scaffold to effectively treat osteomyelitis by removing the biofilm. We proposed an antibiotic-loaded biodegradable polymer scaffold using 3D printing, which was encapsulated by a second antibiotic-containing hydrogel. Then, we successfully established a dual-drug-based scaffold that consisted of a cefazolin (CFZ)-containing polycaprolactone 3D scaffold and a rifampicin (RFP)-loaded alginate hydrogel encapsulating the 3D scaffold. Our scaffold showed a synergistic effect, whereby biofilm formation was inhibited by RFP, which is an external drug, and bacterial activity was inhibited by CFZ, which is an internal drug that increases antibacterial activity. We also confirmed that the dual-drug-based scaffold did not affect the proliferation of human osteoblasts. Our findings suggest that this dual drug delivery system may serve as a new therapeutic treatment for osteomyelitis that overcomes the limitations of individual drugs. Full article
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