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Gels
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Hydrogels in Tissue Engineering 2.0
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Hydrogels in Tissue Engineering 2.0

A special issue of Gels (ISSN 2310-2861).

Deadline for manuscript submissions: closed (30 April 2020) | Viewed by 5506

Special Issue Information

Dear Colleagues,

Hydrogels are an important pillar in tissue engineering applications owing to their high water content and tunable elasticity. They are commonly used for cell encapsulation and drug delivery to promote tissue regeneration and guided differentiation, as well as for studying cell–matrix interactions. Hydrogels can be crosslinked by various mechanisms, including in situ gelling, photopolymerization, self-assembly, and click chemistry. They can be formulated to exhibit tunable viscoelastic properties and into different structures, such as thin films, bulk scaffolds, and micro/nanogels. Hydrogels can be designed with hierarchical structures that mimic the complex milieus of an extracellular matrix. Hydrogels can also be prepared to deliver drugs and growth factors at different time scales. As a result, these diverse forms of hydrogels are being actively used for both basic and translational sciences. In this Special Issue, we welcome submissions of expert reviews and original research articles with topics related to using hydrogels in tissue engineering applications.

  • Hydrogels with hierarchical structures;
  • Self-assembled, self-healing, and injectable hydrogels;
  • Hybrid and degradable hydrogels;
  • Hydrogels for studying cell–matrix interactions;
  • Hydrogels for spatiotemporal delivery of drugs and growth factors;
  • Hydrogels for bioprinting and biofabrication;
  • Hydrogels for micropatterning and microfluidic devices;
  • Hydrogels for high-content analysis and high-throughput screening;
  • Hydrogels with dynamically tunable mechanics and biochemical properties;
  • Hydrogels to modulate immune and inflammatory response.

Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Gels is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (1 paper)

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Research

16 pages, 2937 KiB  
Article
Bioprinted Three-Dimensional Cell-Laden Hydrogels to Evaluate Adipocyte-Breast Cancer Cell Interactions
by Sarah Chaji, Jenna Al-Saleh and Cheryl T. Gomillion
Gels 2020, 6(1), 10; https://doi.org/10.3390/gels6010010 - 24 Mar 2020
Cited by 32 | Viewed by 5212
Abstract
Three-dimensional (3D) bioprinting, although still in its infancy as a fabrication tool, has the potential to effectively mimic many biological environments. Cell-laden 3D printed structures have demonstrated to be an improvement from the widely used monolayer platforms, largely because of recapitulation of native [...] Read more.
Three-dimensional (3D) bioprinting, although still in its infancy as a fabrication tool, has the potential to effectively mimic many biological environments. Cell-laden 3D printed structures have demonstrated to be an improvement from the widely used monolayer platforms, largely because of recapitulation of native tissue architecture with the 3D structures. Thus, 3D in vitro models have been increasingly investigated for improved modeling of cell and disease systems, such as for breast cancer. In the present work, multicellular cell-laden hydrogels comprised of adipocytes and breast cancer cells were bioprinted and evaluated. An ideal bioink of 3:2 5% alginate was determined to mimic the tissue stiffness observed in a physiological breast cancer tumor environment. Rheological characterization and degradation studies were performed to verify the stability of the artificial breast hydrogel environment. It was found that both the breast cancer cells and adipocytes remained viable directly after printing and throughout the 10-day culture period within the printed hydrogels. Direct printing of the cells in co-culture resulted in morphology changes and variations in cell localization within printed structures. Overall, the feasibility of efficiently fabricating multicellular cell-laden bioprinted models of the breast tumor microenvironment was established. Full article
(This article belongs to the Special Issue Hydrogels in Tissue Engineering 2.0)
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