Development of Nanogels/Microgels for Regenerative Medicine

A special issue of Gels (ISSN 2310-2861). This special issue belongs to the section "Gel Applications".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 1859

Special Issue Editors

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Guest Editor
Department of Immunology, Kyoto Prefectural University of Medicine, Kyōto 602-8566, Japan
Interests: regenerative medicine; immunology; cell reprogramming

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Guest Editor
Department of Biomedical and Chemical Engineering, Syracuse University, Syracuse, NY 13244, USA
Interests: biomaterials; tissue engineering and regenerative medicine; organ-on-a-chip

Special Issue Information

Dear Colleagues,

In recent years, enormous growth in nano-material technology and science has been attained in the biomedical filed. For example, nanosized hydrogels, so-called nanogels, have been reported to provide a feasible drug-delivery system that enables the efficient transfer of chemotherapeutics and short interfering RNA, and slow-release anti-bacterial peptide, growth factors and cytokines on-site. Through the functions, nanogels can inhibit tumor growth, and enhance wound-healing and blood vessel regeneration. Moreover, nanogels are also used as a scaffold for tissue engineering, including bone, cardiac and urethra tissue regeneration. In general, nanogels are highly biocompatible and biodegradable. Nanogels are also considered to be excellent scaffolds for preparing composites as a novel class of advanced materials, which comprise both nanogels and other constituents, such as polymers or inorganic nanoparticles. Thus, the development of nanogels and their effective application will play an important role in the regenerative medicine field.

This Special Issue will provide various reports on the leading edge nanogels’ synthesis and their effective application in regenerative medicine.

Dr. Kenta Yamamoto
Dr. Yuanhui Song
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Gels is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • nanogels
  • regenerative medicine
  • gel application
  • medical field
  • RNAi transfer
  • growth factor release
  • biomedical scaffolds

Published Papers (1 paper)

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16 pages, 2389 KiB  
Cholesterol-Bearing Polysaccharide-Based Nanogels for Development of Novel Immunotherapy and Regenerative Medicine
by Tetsuya Adachi, Yoshiro Tahara, Kenta Yamamoto, Toshiro Yamamoto, Narisato Kanamura, Kazunari Akiyoshi and Osam Mazda
Gels 2024, 10(3), 206; - 18 Mar 2024
Viewed by 1249
Novel functional biomaterials are expected to bring about breakthroughs in developing immunotherapy and regenerative medicine through their application as drug delivery systems and scaffolds. Nanogels are defined as nanoparticles with a particle size of 100 nm or less and as having a gel [...] Read more.
Novel functional biomaterials are expected to bring about breakthroughs in developing immunotherapy and regenerative medicine through their application as drug delivery systems and scaffolds. Nanogels are defined as nanoparticles with a particle size of 100 nm or less and as having a gel structure. Nanogels have a three-dimensional network structure of cross-linked polymer chains, which have a high water content, a volume phase transition much faster than that of a macrogel, and a quick response to external stimuli. As it is possible to transmit substances according to the three-dimensional mesh size of the gel, a major feature is that relatively large substances, such as proteins and nucleic acids, can be taken into the gel. Furthermore, by organizing nanogels as a building block, they can be applied as a scaffold material for tissue regeneration. This review provides a brief overview of the current developments in nanogels in general, especially drug delivery, therapeutic applications, and tissue engineering. In particular, polysaccharide-based nanogels are interesting because they have excellent complexation properties and are highly biocompatible. Full article
(This article belongs to the Special Issue Development of Nanogels/Microgels for Regenerative Medicine)
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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: Glucan dendrimer-nanogel mediated OC-STAMP silencing for treatment of pathogenic bone resorption
Authors: Kenta Yamamoto; Shin-Ichi Sawada; Osam Mazda; Kazunari Akiyoshi; Toshihisa Kawai
Affiliation: 1 Department of Immunology, Kyoto Prefectural University of Medicine 2 Department of Oral Science and Translational Research, College of Dental Medicine, Nova Southeastern University 3 Department of Polymer Chemistry, Graduate School of Engineering, Kyoto University 4 Synergy Institute for Futuristic Mucosal Vaccine Research and Development, Chiba University
Abstract: Osteoclasts-stimulatory trans-membrane protein (OC-STAMP) plays a pivotal role in promotion of cell fusion event during osteoclast-differentiation (osteoclastogenesis) in the context of pathogenic bone resorption. Thus, it is plausible that the bioengineered approach that suppresses OC-STAMP expression can lead to the development of an effective treatment for inflammatory bone resorption diseases, with minimum side effects. Here, we compared two types of novel amphiphilic glucan dendrimer (GD) nanogels (with or without C12) as a carrier of short interfering RNA (siRNA) to silence OC-STAMP. The results showed that C12-GD nanogels is more efficient in the in vitro silencing of OC-STAMP than GD-nanogel, and that local injection of anti-OC-STAMP-siRNA /C12-GD nanogel complex could attenuate bone resorption induced in the mouse model of periodontitis.

Title: Nanogel Engineering for Development of Novel Immunotherapy and Regenerative medicine
Authors: Testuya Adachi
Affiliation: Department of Dental Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine

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