Smart Hydrogels: Application in Tissue Engineering

A special issue of Gels (ISSN 2310-2861). This special issue belongs to the section "Gel Applications".

Deadline for manuscript submissions: closed (31 May 2023) | Viewed by 4782

Special Issue Editors


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Guest Editor
Department of Chemistry and Nanoscience, Ewha Womans University, 52 Ewhayeodae-gil, Seodaemun-gu, Seoul 03760, Korea
Interests: thermogel; tissue engineering; stem cell differentiation
Special Issues, Collections and Topics in MDPI journals
School of Physics, Nanjing University, Nanjing 210093, China
Interests: protein; peptide; hydrogel; single molecule; mechanical properties; self-assembly; force spectroscopy; biomaterials
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Hydrogels are three-dimensional hydrophilic networks that undergo a sol–gel transition and are able to absorb a significant amount of water, and thus show a considerable swelling behavior. Some hydrogels respond to certain chemical (pH and ions) and physical (temperature, electric and magnetic fields, light intensity, and pressure) stimuli and are considered “smart” hydrogels. These hydrogels offer a promising option in various fields ranging from biological to industrial application. Owing to their biocompatibility, hydrogels are of great interest in biomedical applications such as 3D cell scaffolds and tissue regeneration. Additionally, the porous structures are useful for drug delivery systems. The utilization of smart hydrogels has also expanded to biosensors and antibacterial coatings.

This Special Issue “Smart Hydrogels: Application in tissue engineering” focus on recent developments in the biomedical applications of smart hydrogels. In this context, a wide range of topics can be discussed, including 3D cell culture, drug/cell delivery, 3D bioprinting, wound healing and tissue engineering.

Dr. Madhumita Patel
Dr. Yi Cao
Guest Editors

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Published Papers (2 papers)

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Research

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18 pages, 4082 KiB  
Article
Temperature/pH-Sensitive Double Cross-Linked Hydrogels as Platform for Controlled Delivery of Metoclopramide
by Bogdan-Paul Coșman, Sanda-Maria Bucătariu, Marieta Constantin and Gheorghe Fundueanu
Gels 2022, 8(12), 824; https://doi.org/10.3390/gels8120824 - 13 Dec 2022
Cited by 3 | Viewed by 1740
Abstract
Novel double cross-linked (DC) hydrogels with pH-/temperature-sensitive properties were designed and developed. Therefore, linear pH-sensitive poly(methyl vinyl ether-alt-maleic acid) (P(VME/MA)) macromolecules were absorbed within a thermosensitive poly(N-isopropylacrylamide-co-hydroxyethylacrylamide)-hydrogel (PNH) and, subsequently, cross-linked together through a solvent-free thermal method. As a novelty, double [...] Read more.
Novel double cross-linked (DC) hydrogels with pH-/temperature-sensitive properties were designed and developed. Therefore, linear pH-sensitive poly(methyl vinyl ether-alt-maleic acid) (P(VME/MA)) macromolecules were absorbed within a thermosensitive poly(N-isopropylacrylamide-co-hydroxyethylacrylamide)-hydrogel (PNH) and, subsequently, cross-linked together through a solvent-free thermal method. As a novelty, double cross-linked hydrogels were obtained from previously purified polymers in the absence of any solvent or cross-linking agent, which are generally harmful for the body. The new DC structures were characterized by FT–IR spectroscopy, SEM, swelling kinetic measurements, and mechanical tests. The resulting scaffolds exhibited interconnected pores and a flexible pattern, compared to the brittle structure of conventional PNH. The swelling kinetics of DC hydrogels were deeply affected by temperature (25 and 37 °C) and pH (7.4 and 1.2). Furthermore, the hydrogels absorbed a great amount of water in a basic environment and displayed improved mechanical properties. Metoclopramide (Met) was loaded within DC hydrogels as a model drug to investigate the ability of the support to control the drug release rate. The results obtained recommended them as convenient platforms for the oral administration of drugs, with the release of the largest part of the active principle occurring in the colon. Full article
(This article belongs to the Special Issue Smart Hydrogels: Application in Tissue Engineering)
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Review

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9 pages, 3367 KiB  
Review
Intervertebral Disc Tissue Engineering Using Additive Manufacturing
by Minami Yoshida, Paul Richard Turner and Jaydee Dones Cabral
Gels 2023, 9(1), 25; https://doi.org/10.3390/gels9010025 - 29 Dec 2022
Cited by 1 | Viewed by 2517
Abstract
Intervertebral disc (IVD) degeneration is one of the major causes of lower back pain, a common health condition that greatly affects the quality of life. With an increasing elderly population and changes in lifestyle, there exists a high demand for novel treatment strategies [...] Read more.
Intervertebral disc (IVD) degeneration is one of the major causes of lower back pain, a common health condition that greatly affects the quality of life. With an increasing elderly population and changes in lifestyle, there exists a high demand for novel treatment strategies for damaged IVDs. Researchers have investigated IVD tissue engineering (TE) as a way to restore biological and mechanical functions by regenerating or replacing damaged discs using scaffolds with suitable cells. These scaffolds can be constructed using material extrusion additive manufacturing (AM), a technique used to build three-dimensional (3D), custom discs utilising computer-aided design (CAD). Structural geometry can be controlled via the manipulation of printing parameters, material selection, temperature, and various other processing parameters. To date, there are no clinically relevant TE-IVDs available. In this review, advances in AM-based approaches for IVD TE are briefly discussed in order to achieve a better understanding of the requirements needed to obtain more effective, and ultimately clinically relevant, IVD TE constructs. Full article
(This article belongs to the Special Issue Smart Hydrogels: Application in Tissue Engineering)
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