Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
4.7
5.0
Journals
Gels
Special Issues
Recent Advances in Hydrogel Materials
share announcement

Recent Advances in Hydrogel Materials

A special issue of Gels (ISSN 2310-2861). This special issue belongs to the section "Gel Analysis and Characterization".

Deadline for manuscript submissions: 30 September 2025 | Viewed by 547

Special Issue Editors

Dr. Siyuan Chen

E-Mail Website
Guest Editor
College of Materials Science and Engineering, Nanjing Tech University, Nanjing 211816, China
Interests: transdermal delivery; hydrogel-forming microneedles; nano-drug delivery systems; controlled release
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Akira Matsumoto

E-Mail Website
Guest Editor
Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo 101-0062, Japan
Interests: polymer gel; gel; boronic acids; drug delivery systems; biosensors; microneedles
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are delighted to announce this Special Issue on ‘Recent Advances in Hydrogel Materials’. Hydrogels containing three-dimensional networks formed by physical or chemical cross-linking of hydrophilic polymer chains or molecules have shown ideal properties for widespread application. Due to their excellent biodegradability and biocompatibility, controlled degradation, tunable physical properties, hydrophilicity, softness, and fluffiness, their play important roles in biomedical applications. Hydrogel materials have also gained attention for their use in energy storage, conversion applications, and in the development of wearable sensors. In addition, hydrogels also respond to various stimuli, such as temperature, electric field, magnetic field, biological molecules, and ionic strength, which enable them to meet the requirements for smart applications. This Special Issue provides an excellent platform to share the up-to-date research progress in the design, synthesis, and application of hydrogel materials. Research papers or reviews that showcase the latest advancements and breakthroughs in this field are welcomed. We look forward to receiving your contributions and believe that this Special Issue will promote the development of hydrogel materials.

Dr. Siyuan Chen
Prof. Dr. Akira Matsumoto
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Gels is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2100 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • hydrogels
  • polymers
  • gel synthesis
  • characterization
  • interdisciplinary applications

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

19 pages, 4973 KiB  
Article
Temperature- and pH-Responsive Poly(NIPAM-co-HEMA-co-AAm) Nanogel as a Smart Vehicle for Doxorubicin Delivery; Combating Colorectal Cancer
by Soheila Ghasemi, Mehdi Najafi, Mohammad Doroudian, Banafsheh Rastegari, Abbas Behzad-Behbahani, Hadis Soltanimehr and Fatemeh Farjadian
Gels 2025, 11(4), 227; https://doi.org/10.3390/gels11040227 - 22 Mar 2025
Viewed by 359
Abstract
In this project, a new class of temperature- and pH-sensitive hydrogel consisting of N-isopropyl acrylamide (NIPAM), hydroxyethyl methacrylate (HEMA), and acrylamide (AAm) was prepared via a controlled route through the reversible addition–fragmentation chain-transfer (RAFT) polymerization process. Poly(ethyleneglycol) dimethacrylate (PEG-DMA) was used as [...] Read more.
In this project, a new class of temperature- and pH-sensitive hydrogel consisting of N-isopropyl acrylamide (NIPAM), hydroxyethyl methacrylate (HEMA), and acrylamide (AAm) was prepared via a controlled route through the reversible addition–fragmentation chain-transfer (RAFT) polymerization process. Poly(ethyleneglycol) dimethacrylate (PEG-DMA) was used as a long-chain hydrophilic and biocompatible crosslinking agent. The hydrogel structure was confirmed by different characteristic techniques such as 1H NMR, FT-IR, and SEC, and the morphology and particle diameters were checked via the scanning electron microscopy (SEM) and dynamic light scattering (DLS) methods. Afterward, the as-prepared hydrogel, poly(NIPAM-co-HEMA-co-AAm), was loaded with doxorubicin (DOX) to be used as a temperature- and pH-triggered delivery carrier. The prepared system released DOX slowly at 37 °C and neutral pH, but increased DOX release significantly at 42 °C and acidic pH. The anti-cancer efficiencies of free DOX, hydrogel, and the DOX–hydrogel conjugate were tested in vitro using human colorectal adenocarcinoma HT-29 cell lines. Cytotoxicity evaluation of free DOX compared with the DOX–hydrogel conjugate revealed that more cancer cells were killed with increasing concentration. Moreover, the DOX-mediated apoptosis and ROS levels showed the beneficial effects of poly(NIPAM-co-HEMA-co-AAm) hydrogel for cancer drug delivery. Generally, the results suggest that this system can be a potential candidate for designing drug delivery systems. Full article
(This article belongs to the Special Issue Recent Advances in Hydrogel Materials)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-1
Back to TopTop