Advances in Hydrogels for Regenerative Medicine

A special issue of Gels (ISSN 2310-2861). This special issue belongs to the section "Gel Processing and Engineering".

Deadline for manuscript submissions: 10 September 2025 | Viewed by 1339

Special Issue Editors


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Guest Editor
Institute of Electronics, Computer and Telecommunication Engineering (IEIIT), National Research Council of Italy (CNR), 20133 Milan, Italy
Interests: biomaterials; nanotechnology; tissue regeneration; EMF for health; cell–material interactions; stimuli-responsive materials; computational material science
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Guest Editor
College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China
Interests: polymer materials; hydrogel

Special Issue Information

Dear Colleagues,

Hydrogels have gained significant attention in regenerative medicine due to their remarkable ability to mimic the extracellular matrix, support cell proliferation, and facilitate targeted drug delivery. These highly versatile materials are engineered to provide suitable mechanical properties, biocompatibility, and degradation rates, making them ideal for tissue engineering, wound healing, and controlled release applications. Advances in hydrogel design and functionalization continue to open new pathways for customized medical solutions, addressing complex challenges in tissue regeneration and therapeutic delivery.

Given the pivotal role of hydrogels in emerging biomedical applications, we are pleased to invite you to submit your latest findings and insights on hydrogels in regenerative medicine to contribute to this rapidly evolving area. This Special Issue aims to bring together research and review articles focusing on the latest advancements in hydrogel technologies specifically tailored for regenerative medicine. The goal is to provide a comprehensive collection of studies that highlight innovative approaches to scaffold design, cell–matrix interactions, and drug release mechanisms within the scope of regenerative medicine. The submission of both theoretical and experimental studies is welcome.

In this Special Issue, we welcome original research articles and reviews that cover, but are not limited to, the following topics:

  • Design and synthesis of novel hydrogels for tissue engineering applications;
  • Smart hydrogels for controlled drug delivery in regenerative medicine;
  • Stimuli-responsive hydrogels activated by ultrasound, electromagnetic fields, or other external factors;
  • Biofunctionalization of hydrogels for cell integration;
  • Hydrogels in 3D bioprinting and scaffold development;
  • Injectable hydrogels for minimally invasive regenerative therapies;
  • Mechanistic studies of hydrogel degradation and bio-resorption in vivo;
  • Application of hydrogels in wound healing and skin regeneration;
  • Hydrogel-based microenvironments for stem cell differentiation and tissue regeneration;
  • Computational modeling and simulation of hydrogel behavior in biological environments.

We look forward to receiving your contributions.

Dr. Martina Lenzuni
Dr. Dongdong Zhou
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Gels is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2100 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • hydrogels
  • regenerative medicine
  • biomaterials
  • tissue engineering
  • drug delivery
  • 3D bioprinting
  • scaffold design
  • biocompatibility
  • stimuli-responsive hydrogels

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Published Papers (1 paper)

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Review

26 pages, 2983 KiB  
Review
3D-Printed Hydrogels from Natural Polymers for Biomedical Applications: Conventional Fabrication Methods, Current Developments, Advantages, and Challenges
by Berk Uysal, Ujith S. K. Madduma-Bandarage, Hasani G. Jayasinghe and Sundar Madihally
Gels 2025, 11(3), 192; https://doi.org/10.3390/gels11030192 - 9 Mar 2025
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Abstract
Hydrogels are network polymers with high water-bearing capacity resembling the extracellular matrix. Recently, many studies have focused on synthesizing hydrogels from natural sources as they are biocompatible, biodegradable, and readily available. However, the structural complexities of biological tissues and organs limit the use [...] Read more.
Hydrogels are network polymers with high water-bearing capacity resembling the extracellular matrix. Recently, many studies have focused on synthesizing hydrogels from natural sources as they are biocompatible, biodegradable, and readily available. However, the structural complexities of biological tissues and organs limit the use of hydrogels fabricated with conventional methods. Since 3D printing can overcome this barrier, more interest has been drawn toward the 3D printing of hydrogels. This review discusses the structure of hydrogels and their potential biomedical applications with more emphasis on natural hydrogels. There is a discussion on various formulations of alginates, chitosan, gelatin, and hyaluronic acid. Furthermore, we discussed the 3D printing techniques available for hydrogels and their advantages and limitations. Full article
(This article belongs to the Special Issue Advances in Hydrogels for Regenerative Medicine)
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