Gel Biomaterials for Antibacterial and Biomedical Applications

A special issue of Gels (ISSN 2310-2861). This special issue belongs to the section "Gel Applications".

Deadline for manuscript submissions: 20 January 2027 | Viewed by 1025

Special Issue Editor


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Guest Editor
Department of Biofibers and Biomaterials Science, Kyungpook National University, Daegu 41566, Republic of Korea
Interests: tissue engineering; hydrogels; microfluidics; nanofibers; biosensors

Special Issue Information

Dear Colleagues,

The development of gel biomaterials has profoundly transformed the landscape of biomedical research, offering unprecedented opportunities for addressing one of the most pressing challenges in modern medicine: bacterial infection. Since the early exploration of hydrogels as biomedical scaffolds, remarkable progress has been made in engineering gel-based platforms with tailored physicochemical properties, biocompatibility, and multifunctional bioactivity. Today, gel biomaterials stand at the forefront of antibacterial research, serving as versatile tools for wound healing, tissue engineering, and localized drug delivery. Despite these advances, the escalating threat of antibiotic-resistant pathogens has created an urgent demand for next-generation antibacterial strategies that move beyond conventional antibiotic therapies. Gel biomaterials offer a compelling solution, enabling the sustained and localized release of antimicrobial agents, the incorporation of bioactive nanoparticles, and the design of stimuli-responsive systems capable of on-demand antibacterial action. However, many fundamental questions regarding the optimization of gel formulations, the mechanisms of antibacterial performance, and the translation of laboratory findings into clinical practice remain to be fully addressed. We believe it is time to consolidate the growing body of knowledge in this field and to chart a new course for the rational design of gel biomaterials for antibacterial and biomedical applications. This Special Issue welcomes the submission of both original research articles and comprehensive review papers, including, but not limited to, antibacterial hydrogels, wound healing platforms, tissue engineering scaffolds, and drug delivery systems based on gel biomaterials. We look forward to receiving contributions from researchers across materials science, biomedical engineering, and microbiology.

Dr. Kihak Gwon
Guest Editor

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Keywords

  • hydrogel
  • antibacterial
  • wound healing
  • tissue engineering
  • drug delivery
  • biomaterials

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Published Papers (1 paper)

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Review

29 pages, 1746 KB  
Review
Formulation-Dependent Antibacterial Performance: Design and Biomedical Applications
by Ji Won Choi, Younghee Kim, MeeiChyn Goh and Kihak Gwon
Gels 2026, 12(4), 310; https://doi.org/10.3390/gels12040310 - 3 Apr 2026
Viewed by 779
Abstract
Over the past decade, antibacterial materials have become a promising strategy to address both antibiotic-resistant and biomaterial-associated infections in clinical settings. Despite substantial progress, a gap remains between promising antibacterial performance in vitro and limited therapeutic outcomes in vivo. Herein, we present a [...] Read more.
Over the past decade, antibacterial materials have become a promising strategy to address both antibiotic-resistant and biomaterial-associated infections in clinical settings. Despite substantial progress, a gap remains between promising antibacterial performance in vitro and limited therapeutic outcomes in vivo. Herein, we present a mechanistic framework for understanding formulation-dependent antibacterial performance across five representative formulation architectures: nanoparticle-based systems, nanofibrous scaffolds, hydrogel matrices, surface coatings, and vesicular or microencapsulated carriers. We impart how structural organization and delivery dynamics regulate antibacterial mechanisms such as contact-mediated killing, controlled therapeutic release, and reactive oxygen species (ROS) generation and discuss their context-dependent suitability for diverse infection scenarios; these include acute wound infections, biofilm-associated implant infections, and chronic infected wounds. Particular emphasis is placed on factors contributing to the frequent failure of high in vitro log reduction efficacy translating into clinical success, including protein corona formation, biological barrier penetration, and dynamic host–pathogen interactions. Finally, we propose a comparative formulation-selection framework based on infection type, tissue environment, and therapeutic objectives to guide the rational design of next-generation antibacterial materials. This perspective bridges the gap between material innovation and clinical translation by highlighting formulation architecture as a central determinant of antibacterial performance in biomedical applications. Full article
(This article belongs to the Special Issue Gel Biomaterials for Antibacterial and Biomedical Applications)
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