Therapeutic Strategies for Diabetic Kidney Disease
A special issue of Diabetology (ISSN 2673-4540).
Deadline for manuscript submissions: closed (25 May 2022) | Viewed by 6428
Special Issue Editors
Interests: diabetes; diabetic kidney disease; diabetic nephropathy; obesity; Rho-kinase; ROCK
Special Issue Information
Dear colleagues,
Diabetic kidney disease (DKD) is a worldwide public health concern. It is the leading cause of end-stage renal disease (ESRD) and is strongly associated with high cardiovascular death rate in patients with diabetes. The pathological significance of activated renin-angiotensin system (RAS) and hemodynamic changes is becoming increasingly evident, and a large number of diabetic patients are treated with RAS and/or SGLT2 inhibitors. While currently approved, these agents can retard but not completely prevent the progression to ESRD and cardiovascular events. Given the importance of DKD as a major risk factor for macrovascular complications, it is important to understand how this disease progresses and how the vascular disease is involved.
In this Special Issue of Diabetology, we invite researchers to submit original research articles as well as review articles focusing on the molecular mechanisms of DKD. Contributions demonstrating original therapeutic opportunities or strategies for reducing cardiovascular complications are also encouraged.
Dr. Keiichiro Matoba
Dr. Naga Samji
Guest Editors
Manuscript Submission Information
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Keywords
- diabetic kidney disease
- diabetes
- obesity
- insulin resistance
- endothelial dysfunction
- atherosclerosis
- reno-cardiac syndrome
- renin-angiotensin system
- inflammation
- oxidative stress
- signaling cascade
- mitochondrial homeostasis
- therapeutic approaches
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