Advances in Functional Cocrystals

Dear Colleagues,

The field of cocrystals is rapidly growing in solid-state science, comprising crystal engineers, pharmaceutical researchers, chemists, chemical engineers, computational researchers from academia and industry. Cocrystals, being the multicomponent solids incorporating two or more solids in a crystal lattice, show great promise in modulating physicochemical properties of the constituents. Last few decades have witnessed an enormous advancement in the design and synthesis of cocrystals which paved the way for novel drug products and improved functional materials.

The current special issue makes an attempt to showcase recent developments in the functional cocrystals and current research interests within the broad theme of cocrystals. The focus of the issue covers, but not limited to, control of physicochemical attributes henceforth bioavailability, stability and manufacturability of active pharmaceutical ingredient into solid dosage form via pharmaceutical cocrystals, polymorphism in cocrystals, behaviour of cocrystals in solution media, cocrystal formulations and scale up of cocrystals from laboratory to large-scale production. Recent studies show that, beside pharmaceuticals, cocrystallization can also be used to modify the properties of nutraceuticals, agrochemicals and specialty chemicals, explosives, and optical properties of materials such as thermochromism, modulated fluorescence and photolithography. Tailored modulation of magnetic and electronic properties of materials by cocrystallization is an emerging area of research in the recent times. In addition to experimental approaches with cocrystals, there has been considerable success with rational design and computational prediction of cocrystals supported by over million crystal structures and statistical information that can be retrieved from Cambridge Structural Database.

The current Special Issue on “Advances in Functional Cocrystals” serves as an excellent international platform to report results that highlight design and synthesis of cocrystals and their potential applications in wide-range of research fields. We invite contributions from scientists working in all disciplines related to the development of cocrystals. We hope that readers will find this issue both interesting and stimulating.

Dr. Venu Vangala
Dr. Srinivasulu Aitipamula
Guest Editors

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