Dear Colleagues,

To advance the replacement of animal testing with alternative test methods, some OECD test guidelines (TGs) have been approved as alternatives to in vivo test methods. These TGs were approved for the UN GHS (United Nations Globally Harmonized System of Classification and Labelling of Chemicals) classification of general chemical substances. It is generally accepted in TGs that no single in vitro test method is able to fully replace in vivo tests to predict across the full range of irritation for different chemical classes, but they do not simply constitute an evaluation method for final cosmetic products and ingredients. Therefore, strategic combinations of alternative test methods within a (tiered) testing strategy and/or integrated approaches to testing and assessment (IATA) were developed to replace the in vivo test. The purpose of IATA underpins the integration of novel methods and data in an exposure-led approach for the safety assessment of cosmetic ingredients. In this situation, we must incorporate new approach methodologies (NAMs) into an integrated strategy for risk assessment of cosmetic ingredients (or ‘Next Generation’ risk assessment: NGRA), along with examples showing their usefulness to safety evaluation. In this Special Issue, the authors will describe principles, NAMs and case reports for “Cosmetic Safety and NGRA” without animal experiments.

Dr. Hajime Kojima
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cosmetics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• alternative
• cosmetic ingredient
• cosmetic product
• exposure
• non-animal
• IATA (integrated approaches to testing and assessment)
• NAM (new approach methodology)
• NGRA (next generation risk assessment)