Multifunctional Bioactive Coatings for Orthopaedic Applications

A special issue of Coatings (ISSN 2079-6412). This special issue belongs to the section "Bioactive Coatings and Biointerfaces".

Deadline for manuscript submissions: closed (10 January 2022) | Viewed by 377

Special Issue Editor


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Guest Editor
Department of Orthopaedic Surgery, National University of Singapore, Singapore 119077, Singapore
Interests: tissue engineering; 3D printing; bone implants; osteoblasts; drug delivery; nanoparticle design

Special Issue Information

Dear Colleagues,

Functional mobility is one of the basic needs of mankind. However, as one ages, joint degeneration and inflammation become chronic conditions that affect mobility and independence. Most of the joint conditions are treated surgically with orthopaedic implants. Due to a rise in aging population, the demands of orthopedic prosthetics have escalated and the global market size is predicted to reach USA 79.5 billion by 2030 at a CAGR of 5%.

Orthopedic implants are engineered to be biocompatible and must restore the tissue function without eliciting an immune response. However, implant failure remains a common problem in orthopaedics; hence, patients suffer from prolonged pain and antibiotic therapy, extended hopitilisation, and are exposed to additional risks that are involved with revision surgeries. Implant failure may be caused due to various reasons, such as infection, foreign body reaction, inflammation, fibrosis, sub-optimal osseointegration, etc. Hence, there is a great demand for biomaterials that excel in biocompatibility and osseointegration.

Recently, scientists have innovated various kinds of surface coatings and surface treatments to tailor cellular activity at the bone–implant interface. Modifications to surface topology (e.g., roughness, morphology) and surface chemistry (e.g., coating with growth factors, osteogenic ions, osteogenic and antibacterial drugs, etc.) are known to improve osseointegration and longevity of the implants. This Special Issue of Coatings aims to present the latest developments in the field, through original research articles, reviews, and communications. Areas of interest include, but are not limited to:

  1. Multifunctional coatings to improve bone cell activity;
  2. Surface modification for localised delivery of drugs;
  3. Surface coatings to improve osseointegration;
  4. Novel coatings to suppress biofilm formation;
  5. Innovative coatings to reduce fibrosis.
Dr. Chris Steffi
Guest Editor

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Keywords

  • Osseointegration
  • Surface functionalisation
  • Septic and aseptic loosening
  • Biofilm
  • Fibrosis

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Published Papers

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