Special Issue "Catalytic Organic Transformations/Organic Synthesis"

A special issue of Catalysts (ISSN 2073-4344). This special issue belongs to the section "Catalysis in Organic and Polymer Chemistry".

Deadline for manuscript submissions: closed (20 November 2021).

Special Issue Editors

Prof. Dr. Jae-Sang Ryu
E-Mail Website
Guest Editor
College of Pharmacy & Graduate School of Pharmaceutical Sciences, Ewha Womans University, 52 Ewhayeodae-gil, Seodaemun-Gu, Seoul 03760, Korea
Interests: transition-metal catalysis; asymmetric catalysis; total synthesis; diversity-oriented synthesis; heterocyclic chemistry; medicinal chemistry; drug conjugate
Prof. Dr. Bimal Krishna Banik
E-Mail Website
Guest Editor
Department of Mathematics and Natural Sciences; College of Sciences and Human StudiesDeanship of Research Development, Prince Mohammad Bin Fahd University, P. O. Box 1664, Al Khobar 31952, Saudi Arabia
Interests: organic synthesis; medicinal chemistry; cancer; green chemistry; microwave; drug discovery; natural product synthesis; mechanism of chemical and biological processes; interdisciplinary sciences

Special Issue Information

Dear Colleagues,

In the domain of synthetic organic chemistry, catalysts play a crucial role in the synthesis of new molecules of diverse interests. A vast array of researchers involves exploring the molecules that stimulate organic transformations. The scope of catalysis in chemistry is reasonably comprehensive. The term catalysis was first proposed by Jöns Jakob Berzelius in 1835. Since its inception, Paul Sabatier discovered that a trace amount of Nickle metal can assist the addition of hydrogen to olefinic bond. This remarkable discovery revolutionized the field of catalysis. Over the past several decades, huge efforts have been devoted to establishing the utility of the wide range of metal, non-metal, and small organic molecules in triggering organic transformations exhaustively. Despite the spectacular successes in the catalysis process, innovative catalytic systems are highly demanding.

In this regard, this Special Issue on “Catalytic Organic Transformations/Organic Synthesis” offers an opportunity to researchers to submit their scientific output. Review articles, original research manuscripts, and communication articles featuring the role of catalysts in the following domain will be considered: (i) biocatalysts in organic synthesis; (ii) molecular catalysis in the synthesis of bioactive molecules; (iii) transition-metal-catalyzed synthesis and green synthesis in organic and medicinal chemistry; (iv) (heterogeneous) photocatalysis; and (v) metal-salts-catalyzed reactions.

Prof. Dr. Jae-Sang Ryu
Prof. Dr. Bimal Krishna Banik
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Catalysts is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • metal catalysis
  • green synthesis
  • natural products
  • medicinal chemistry
  • hetero and carbocyclic chemistry
  • organocatalysis
  • stereoselective synthesis

Published Papers (4 papers)

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Research

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Article
Gold(I)-Catalyzed Tandem Synthesis of Polycyclic Dihydroquinazolinones
Catalysts 2021, 11(12), 1436; https://doi.org/10.3390/catal11121436 - 25 Nov 2021
Viewed by 168
Abstract
A gold-catalyzed cascade process for the synthesis of dihydroquinazolinone scaffolds was developed. A series of gold catalysts were screened for this tandem transformation, and the (PPh3)AuCl/AgOTf catalyst combination was found to be the best catalyst system. This method is characterized by [...] Read more.
A gold-catalyzed cascade process for the synthesis of dihydroquinazolinone scaffolds was developed. A series of gold catalysts were screened for this tandem transformation, and the (PPh3)AuCl/AgOTf catalyst combination was found to be the best catalyst system. This method is characterized by good yields, high regioselectivity, and broad substrate scope. This method is also applicable to the synthesis of tetracyclic dihydroquinazolinones and seven-membered ring-fused dihydroquinazolinones. Full article
(This article belongs to the Special Issue Catalytic Organic Transformations/Organic Synthesis)
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Article
The Efficient Recyclable Molybdenum- and Tungsten-Promoted Mesoporous ZrO2 Catalysts for Aminolysis of Epoxides
Catalysts 2021, 11(6), 673; https://doi.org/10.3390/catal11060673 - 25 May 2021
Viewed by 604
Abstract
In the present study, we report the synthesis and catalytic activity of tungsten- and molybdenum-promoted mesoporous metal oxides in the aminolysis of epoxides. The as-synthesized catalysts were fully characterized by a variety of techniques such as transmission electron microscopy (TEM), scanning electron microscopy [...] Read more.
In the present study, we report the synthesis and catalytic activity of tungsten- and molybdenum-promoted mesoporous metal oxides in the aminolysis of epoxides. The as-synthesized catalysts were fully characterized by a variety of techniques such as transmission electron microscopy (TEM), scanning electron microscopy (SEM), temperature-programmed reduction (TPR) and desorption (TPD), nitrogen sorption measurements, powder X-ray diffraction (p-XRD), and thermogravimetric analysis (TGA). Amongst the two supports utilized, ZrO2 is a better support compared to SiO2. Furthermore, MoO3 proved to be a better dopant compared to its counterpart. Several parameters such as the variation of solvents, substrates, catalyst amounts, and stirring speed were investigated. It was observed that 450 rpm was the optimum stirring speed, with toluene as the best solvent and styrene oxide as the best substrate. Moreover, the optimum parameters afforded 98% conversion with 95% selectivity towards 2-phenyl-2-(phenylamino) ethanol and 5% towards 1-phenyl-2-(phenylamino) ethanol. Furthermore, 5%MoO3-ZrO2 catalyst demonstrated optimal performance and it exhibited excellent activity as well as great stability after being recycled 6 times. Full article
(This article belongs to the Special Issue Catalytic Organic Transformations/Organic Synthesis)
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Review

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Review
Regiodivergent Organocatalytic Reactions
Catalysts 2021, 11(8), 1013; https://doi.org/10.3390/catal11081013 - 22 Aug 2021
Viewed by 804
Abstract
Organocatalysts are abundantly used for various transformations, particularly to obtain highly enantio- and diastereomeric pure products by controlling the stereochemistry. These applications of organocatalysts have been the topic of several reviews. Organocatalysts have emerged as one of the very essential areas of research [...] Read more.
Organocatalysts are abundantly used for various transformations, particularly to obtain highly enantio- and diastereomeric pure products by controlling the stereochemistry. These applications of organocatalysts have been the topic of several reviews. Organocatalysts have emerged as one of the very essential areas of research due to their mild reaction conditions, cost-effective nature, non-toxicity, and environmentally benign approach that obviates the need for transition metal catalysts and other toxic reagents. Various types of organocatalysts including amine catalysts, Brønsted acids, and Lewis bases such as N-heterocyclic carbene (NHC) catalysts, cinchona alkaloids, 4-dimethylaminopyridine (DMAP), and hydrogen bond-donating catalysts, have gained renewed interest because of their regioselectivity. In this review, we present recent advances in regiodivergent reactions that are governed by organocatalysts. Additionally, we briefly discuss the reaction pathways of achieving regiodivergent products by changes in conditions such as solvents, additives, or the temperature. Full article
(This article belongs to the Special Issue Catalytic Organic Transformations/Organic Synthesis)
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Review
Asymmetric Catalytic Ketimine Mannich Reactions and Related Transformations
Catalysts 2021, 11(6), 712; https://doi.org/10.3390/catal11060712 - 07 Jun 2021
Cited by 2 | Viewed by 979
Abstract
The catalytic enantioselective ketimine Mannich and its related reactions provide direct access to chiral building blocks bearing an α-tertiary amine stereogenic center, a ubiquitous structural motif in nature. Although ketimines are often viewed as challenging electrophiles, various approaches/strategies to circumvent or overcome the [...] Read more.
The catalytic enantioselective ketimine Mannich and its related reactions provide direct access to chiral building blocks bearing an α-tertiary amine stereogenic center, a ubiquitous structural motif in nature. Although ketimines are often viewed as challenging electrophiles, various approaches/strategies to circumvent or overcome the adverse properties of ketimines have been developed for these transformations. This review showcases the selected examples that highlight the benefits and utilities of various ketimines and remaining challenges associated with them in the context of Mannich, allylation, and aza-Morita–Baylis–Hillman reactions as well as their variants. Full article
(This article belongs to the Special Issue Catalytic Organic Transformations/Organic Synthesis)
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