Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
6.8
3.8
Journals
Catalysts
Special Issues
Catalytic Asymmetric Epoxidation: Recent Progress
share announcement

Catalytic Asymmetric Epoxidation: Recent Progress

A special issue of Catalysts (ISSN 2073-4344). This special issue belongs to the section "Catalysis in Organic and Polymer Chemistry".

Deadline for manuscript submissions: closed (20 October 2021) | Viewed by 31252

Special Issue Editor

Dr. Gerasimos Rassias

E-Mail Website
Guest Editor
Department of Chemistry, University of Patras, 26504 Patras, Greece
Interests: medicinal chemistry (lead optimization for antiviral, oncology and CNS targets); 2nd generation processes for improving the synthesis of drug molecules (original and generic); green chemistry; asymmetric synthesis; metal- and organocatalysis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Epoxides (oxiranes) constitute an important class of compounds both in biology and chemistry. The epoxide functionality is found in many natural products of diverse biological properties, in pharmaceutical molecules and in synthetic intermediates towards the synthesis of more complex compounds which support a range of applications such as medicine, polymers and other high-performance materials. Over the past decades, the synthesis and further exploitation of epoxides has been the subject of intense research efforts and significant advances have been made across all fronts of their chemistry and biology and uses thereof. Several reviews and book chapters have been dedicated to specific aspects of the epoxide field; yet, significant developments continue to emerge, rendering the epoxide moiety a special theme that continues to attract substantial interest. It is therefore warranted that the most recent developments in the epoxide field be captured and communicated in a concise and holistic manner. This Special Issue intends to serve this purpose and constitute a point of reference with respect to: (a) natural occurrence, properties, and reactivity of epoxides; (b) epoxidation methods (direct/indirect, stoichiometric/catalysed, regio-, distrereo- and enantioselective); and (c) applications and future prospects in research and industry.

Dr. Gerasimos Rassias
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Catalysts is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review

9 pages, 1920 KiB  
Article
Manganese Catalysts with Tetradentate N-donor Pyridine-Appended Bipiperidine Ligands for Olefin Epoxidation Reactions: Ligand Electronic Effect and Mechanism
by Fengfan Zhu, Guang Yang, Adam J. Zoll, Elena V. Rybak-Akimova and Xinbao Zhu
Catalysts 2020, 10(3), 285; https://doi.org/10.3390/catal10030285 - 2 Mar 2020
Cited by 9 | Viewed by 4299
Abstract
In this work, we described an electron-rich manganese mesoPYBP catalyst, Mn-SR-mesoPYBP(ClO4)2, by introducing electron-donating substituents on the mesoPYBP ligand. We optimized the catalytic performance in olefin epoxidation with H2O2 in the presence [...] Read more.
In this work, we described an electron-rich manganese mesoPYBP catalyst, Mn-SR-mesoPYBP(ClO4)2, by introducing electron-donating substituents on the mesoPYBP ligand. We optimized the catalytic performance in olefin epoxidation with H2O2 in the presence of acetic acid. The electron paramagnetic resonance (EPR) and cyclic voltammetry (CV) studies supported that an electronic effect could stabilize the high-valent intermediates in the catalytic cycles of the catalyst, which largely improved the catalytic performance and the reactivity of olefin epoxidation. Full article
(This article belongs to the Special Issue Catalytic Asymmetric Epoxidation: Recent Progress)
►▼ Show Figures

Graphical abstract

Review

Jump to: Research

65 pages, 11791 KiB  
Review
Epoxide Syntheses and Ring-Opening Reactions in Drug Development
by Fotini Moschona, Ioanna Savvopoulou, Maria Tsitopoulou, Despoina Tataraki and Gerasimos Rassias
Catalysts 2020, 10(10), 1117; https://doi.org/10.3390/catal10101117 - 27 Sep 2020
Cited by 96 | Viewed by 26016
Abstract
This review concentrates on success stories from the synthesis of approved medicines and drug candidates using epoxide chemistry in the development of robust and efficient syntheses at large scale. The focus is on those parts of each synthesis related to the substrate-controlled/diastereoselective and [...] Read more.
This review concentrates on success stories from the synthesis of approved medicines and drug candidates using epoxide chemistry in the development of robust and efficient syntheses at large scale. The focus is on those parts of each synthesis related to the substrate-controlled/diastereoselective and catalytic asymmetric synthesis of epoxide intermediates and their subsequent ring-opening reactions with various nucleophiles. These are described in the form of case studies of high profile pharmaceuticals spanning a diverse range of indications and molecular scaffolds such as heterocycles, terpenes, steroids, peptidomimetics, alkaloids and main stream small molecules. Representative examples include, but are not limited to the antihypertensive diltiazem, the antidepressant reboxetine, the HIV protease inhibitors atazanavir and indinavir, efinaconazole and related triazole antifungals, tasimelteon for sleep disorders, the anticancer agent carfilzomib, the anticoagulant rivaroxaban the antibiotic linezolid and the antiviral oseltamivir. Emphasis is given on aspects of catalytic asymmetric epoxidation employing metals with chiral ligands particularly with the Sharpless and Jacobsen–Katsuki methods as well as organocatalysts such as the chiral ketones of Shi and Yang, Pages’s chiral iminium salts and typical chiral phase transfer agents. Full article
(This article belongs to the Special Issue Catalytic Asymmetric Epoxidation: Recent Progress)
►▼ Show Figures

Scheme 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-2
Back to TopTop