Special Issue "Biocatalytic Cascade Reactions (in vivo and in vitro)"

A special issue of Catalysts (ISSN 2073-4344). This special issue belongs to the section "Biocatalysis".

Deadline for manuscript submissions: 30 November 2020.

Special Issue Editors

Dr. Sandy Schmidt
Guest Editor
Groningen Research Institute of Pharmacy, Chemical and Pharmaceutical Biology, Anthonius Deusinglaan 1, 9713AV Groningen, The Netherlands
Interests: Main research interests focus on the design and assembly of synthetic metabolic pathways and multi-enzymatic cascades as well as the application of enzyme engineering and computational design for the development of new biocatalytic and regulatory functions. Of further interest is the investigation of electron transfer pathways in oxidoreductases and light-driven biocatalytic processes as well as structure–function relationships of dioxygenases and ferredoxin-dependent enzymes and their interactions.
Dr. Thomas Bayer
Guest Editor
University of Greifswald, Institute of Biochemistry, Biotechnology & Enzyme Catalysis, Felix-Hausdorff-Straße 4, 17487 Greifswald, Germany
Interests: Main research interests focus on the bioinformatic-assisted discovery of novel biocatalysts and functional annotation, the assembly of (engineered) enzymes into artificial metabolic pathways, as well as their optimization in microbial hosts for the production of active pharmaceutical ingredients and other value-added chemicals. Of special interest are synthetic biology tools for the contextualization, dynamic control, and regulation of de novo pathways.

Special Issue Information

Dear Colleagues,

The discovery of novel enzymes and their customization by protein engineering techniques is rapidly expanding the toolbox of biocatalysts available for the synthesis of value-added chemicals—both natural and non-natural compounds. Enzymes with their inherently high chemo-, regio-, and stereo-specificities can efficiently operate in vitro and in vivo. In the last two decades, the combination of multiple biocatalysts in (artificial) cascades has yielded awe-inspiring complex molecules from rather simple precursors, while the design and optimization of such cascade reactions has addressed social and environmental concerns including the stewardship of resources and the reduction of waste.

The topic of this Special Issue encompasses cascades employing (engineered) enzymes that operate simultaneously in one pot—either a reaction tube or a living cell—or in a sequential fashion in vitro, in vivo, or in hybrid systems. Enzymes may be applied in isolated form, immobilized, as cell-free extracts, as whole-cell biocatalysts, as well as in combination with metal- and organo-catalysts or in entirely unprecedented forms.

The aim of this Special Issue is to highlight current developments in the fields of biocatalysis and cascade design and to grasp emerging trends that will facilitate the manufacturing of chemicals, pharmaceuticals, and highly demanded ingredients of the future … already today!

Dr. Sandy Schmidt
Dr. Thomas Bayer
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Catalysts is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • biocatalysis 
  • (artificial) enzyme cascades 
  • biotransformations 
  • whole-cell catalysis 
  • metabolic pathways 
  • cofactors 
  • chemo-enzymatic synthesis 
  • microbial cell factories 
  • synthetic biology

Published Papers

This special issue is now open for submission.
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