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Catalysts
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Recent Catalysts for Organic Synthesis
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Recent Catalysts for Organic Synthesis

A special issue of Catalysts (ISSN 2073-4344). This special issue belongs to the section "Catalysis in Organic and Polymer Chemistry".

Deadline for manuscript submissions: 30 November 2025 | Viewed by 3054

Special Issue Editors

Prof. Dr. Lianghua Zou

E-Mail Website
Guest Editor
Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Pharmaceutical Sciences, Jiangnan University, Wuxi 214122, China
Interests: metal catalysis; heterocycle synthesis; annulation reactions; methodologies; medicinal chemistry
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Zhibing Dong

E-Mail Website
Guest Editor
School of Chemistry and Environmental Engineering, Wuhan Institute of Technology, Wuhan 430205, China
Interests: green chemistry; flow chemistry; photo chemistry; electro chemistry

Special Issue Information

Dear Colleagues,

Over the last century, chemists have made significant and valuable advances to global health with their wisdom and creativity. In particular, the development of the chemical industry has positively impacted lives to an unexpected extent through the construction of new compounds, the invention of new materials, and the discovery of new medicines. These targets could not be achieved without one necessary substance: catalysts. Catalytic reactions can be divided into metal catalysis, organocatalysis, enzyme catalysis, and photo catalysis, and these have played an important role in the construction of structurally complex and valuable molecules. Recently, significant efforts have been made in the development of catalytic reactions. We believe that there should be increasing interest and contributions in exploring novel catalytic reactions and discovering powerful catalysts. Therefore, we are pleased to announce this Special Issue on “Recent Catalysts for Organic Synthesis”.

We invite the scientific community to submit their contributions as original research articles or review articles that describe novel catalytic processes, creative designs and syntheses of catalysts, and applications of such catalysts in the laboratory or industry. In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following:

  1. The synthesis and application of catalysts for metal catalysis, organocatalysis, etc.;
  2. Synthetic methodologies in catalytic reactions.

We look forward to receiving your contributions.

Prof. Dr. Lianghua Zou
Prof. Dr. Zhibing Dong
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Catalysts is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • catalytic reactions
  • metal catalysis
  • organocatalysis
  • synthetic methodologies

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (5 papers)

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Research

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11 pages, 2291 KiB  
Article
Cobalt(II)-Catalyzed C−H Deuteriomethoxylation of Benzamides with CD3OD
by Yu-Yan Tan, Mao-Gui Huang, Wei Feng, Mengyuan Niu, Jia-Wei Li and Yue-Jin Liu
Catalysts 2025, 15(1), 65; https://doi.org/10.3390/catal15010065 - 13 Jan 2025
Viewed by 577
Abstract
Herein, we report a practical example of salicylaldehyde-based cobalt-catalyzed C−H deuteriomethoxylation of benzamides using deuterated methanol, facilitated by 8-aminoquinoline as a directing group. The salicylaldehyde-based cobalt catalyst is user-friendly, and the reaction exhibits broad functional group tolerance, accommodating benzene, heterocycles, and naphthalene rings. [...] Read more.
Herein, we report a practical example of salicylaldehyde-based cobalt-catalyzed C−H deuteriomethoxylation of benzamides using deuterated methanol, facilitated by 8-aminoquinoline as a directing group. The salicylaldehyde-based cobalt catalyst is user-friendly, and the reaction exhibits broad functional group tolerance, accommodating benzene, heterocycles, and naphthalene rings. The synthetic utility of this methodology was demonstrated through a gram-scale reaction and the subsequent removal of the 8-aminoquinoline directing group to yield deuteriomethoxylated benzoic acid. Preliminary mechanistic studies suggest that C−H activation is not the rate-determining step of the reaction. Full article
(This article belongs to the Special Issue Recent Catalysts for Organic Synthesis)
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Scheme 1

12 pages, 1216 KiB  
Article
Copper-Catalyzed Trifluoromethylthiolaton and Radical Cyclization of N-Phenylpent-4-Enamides to Construct SCF3-Substituted γ-Lactams
by Hanyang Zhang, Wen Liu, Jiale Hu, Qian Zhang, Zeguo Fang and Dong Li
Catalysts 2024, 14(11), 797; https://doi.org/10.3390/catal14110797 - 7 Nov 2024
Viewed by 794
Abstract
An efficient method involving copper-catalyzed trifluoromethylthiolation and radical cyclization of N-phenylpent-4-enamides using readily available and stable AgSCF3 as the trifluoromethylthiolating reagent is described. The method enables the synthesis of a series of potential medicinally valuable trifluoromethylthio-substituted γ-lactams and relative 2-oxazolidinone [...] Read more.
An efficient method involving copper-catalyzed trifluoromethylthiolation and radical cyclization of N-phenylpent-4-enamides using readily available and stable AgSCF3 as the trifluoromethylthiolating reagent is described. The method enables the synthesis of a series of potential medicinally valuable trifluoromethylthio-substituted γ-lactams and relative 2-oxazolidinone derivatives with broad functional group compatibility. Mechanistic investigations indicated that this reaction involved amidyl radical-initiated cascade 5-exo-trig cyclization followed by trifluoromethylthiolation, resulting in the formation of new C-N and C-S bonds. Full article
(This article belongs to the Special Issue Recent Catalysts for Organic Synthesis)
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11 pages, 1565 KiB  
Article
Iodine-Mediated One-Pot Synthesis of Imidazo[1,5-a]Pyridines
by Lang Huang, Yarong Liu, Zhipeng Guan and Zhibing Dong
Catalysts 2024, 14(9), 601; https://doi.org/10.3390/catal14090601 - 6 Sep 2024
Viewed by 1034
Abstract
In this report, we developed an efficient one-pot method for the synthesis of 3-phenyl-1-(phenylthio)imidazo[1,5-a]pyridine analogs starting from 2-aminomethylpyridines, benzaldehydes, and sodium benzenesulfinates, which constructed C-N and C-S bonds simultaneously. The method features mild reaction conditions, a wide range of substrates, high [...] Read more.
In this report, we developed an efficient one-pot method for the synthesis of 3-phenyl-1-(phenylthio)imidazo[1,5-a]pyridine analogs starting from 2-aminomethylpyridines, benzaldehydes, and sodium benzenesulfinates, which constructed C-N and C-S bonds simultaneously. The method features mild reaction conditions, a wide range of substrates, high atom utilization, and convenient and easily accessible starting materials. Full article
(This article belongs to the Special Issue Recent Catalysts for Organic Synthesis)
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Review

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21 pages, 16026 KiB  
Review
Recent Advances in Catalytic Atroposelective Synthesis of Axially Chiral Quinazolinones
by Yilin Liu, Jiaoxue Wang, Yanli Yin and Zhiyong Jiang
Catalysts 2025, 15(5), 426; https://doi.org/10.3390/catal15050426 - 27 Apr 2025
Viewed by 147
Abstract
Quinazolinones, a class of nitrogen-containing heterocyclic compounds, occupy a crucial position in medicinal chemistry and materials science due to their significant application potential. In recent years, the catalytic asymmetric synthesis of axially chiral quinazolinones has emerged as a prominent research area, driven by [...] Read more.
Quinazolinones, a class of nitrogen-containing heterocyclic compounds, occupy a crucial position in medicinal chemistry and materials science due to their significant application potential. In recent years, the catalytic asymmetric synthesis of axially chiral quinazolinones has emerged as a prominent research area, driven by their prospective applications in the development of bioactive molecules, design of chiral ligands, and fabrication of functional materials. This review comprehensively summarizes recent advancements in the catalytic asymmetric synthesis of axially chiral quinazolinones, with a particular focus on the construction strategies for the three major structural types: the C–N axis, N–N axis, and C–C axis. Key synthetic methodologies, including atroposelective halogenation, kinetic resolution, condensation–oxidation, and photoredox deracemization, are discussed in detail. In addition, the review provides an in-depth analysis of the applications of various catalytic systems, such as peptide catalysis, enzymatic catalysis, metal catalysis, chiral phosphoric acid catalysis, and others. Despite the substantial progress made thus far, several challenges remain, including the expansion of the substrate scope, enhanced control over stereoselectivity, and further exploration of practical applications, such as drug discovery and asymmetric catalysis. These insights are expected to guide future research towards the development of novel synthetic strategies, the diversification of structural variants, and a comprehensive understanding of their biological activities and catalytic functions. Ultimately, this will foster the continued growth and evolution of this rapidly advancing field. Full article
(This article belongs to the Special Issue Recent Catalysts for Organic Synthesis)
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28 pages, 6502 KiB  
Review
Recent Advances in Enantioselective Transition Metal Catalysis Mediated by Ligand–Substrate Noncovalent Interactions
by Zhen Cao, Dongyang He, Lin Luo and Wenjun Tang
Catalysts 2025, 15(4), 395; https://doi.org/10.3390/catal15040395 - 18 Apr 2025
Viewed by 158
Abstract
Enantioselective transition metal catalysis is undoubtedly a cornerstone at the frontier of chemistry, attracting intense interest from both academia and the pharmaceutical industry. Central to this field is the strategic utilization of noncovalent interactions (NCIs), including hydrogen bonding, ion pairing, and π-system engagements, [...] Read more.
Enantioselective transition metal catalysis is undoubtedly a cornerstone at the frontier of chemistry, attracting intense interest from both academia and the pharmaceutical industry. Central to this field is the strategic utilization of noncovalent interactions (NCIs), including hydrogen bonding, ion pairing, and π-system engagements, which not only drive asymmetric synthesis but also enable precise stereochemical control in transition metal-catalyzed transformations. Recent breakthroughs have unveiled a new generation of rationally designed ligands that exploit ligand–substrate noncovalent interactions, emerging as indispensable tools for stereocontrolled synthesis and setting new paradigms in ligand engineering. These advancements establish a transformative framework for ligand engineering, bridging fundamental mechanistic insights with practical synthetic utility. In this review, the judicious design concepts and syntheses of novel ligands from the past five years were highlighted and their synthetic applications in asymmetric catalysis were detailed. Full article
(This article belongs to the Special Issue Recent Catalysts for Organic Synthesis)
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