Special Issue "Biotransformation Catalyzed by Immobilized Enzyme"

A special issue of Catalysts (ISSN 2073-4344). This special issue belongs to the section "Biocatalysis".

Deadline for manuscript submissions: 31 July 2021.

Special Issue Editors

Prof. Dr. Ulf Hanefeld
Guest Editor
Biocatalysis & Organic Chemistry, Delft University of Technology, Delft, The Netherlands
Interests: enzymes that enable the formation of C–C bonds or catalyze reactions that are chemically extremely difficult to perform, their immobilization and application in organic synthesis
Dr. Yann P. Guiavarc'h
Guest Editor
1. University of Lorraine (UL), Nancy, France
2. The Reactions and Chemical Engineering Laboratory (LRGP), joint unit of CNRS (National Center for Scientific Research) and UL, team “Bioprocesses-Biomolecules”, Nancy, France
Interests: enzymes, in particular aminoacylases for performing N-acylation reactions in aqueous phase, and lipases for performing O-acylation reactions in anhydrous solvents (supercritical CO2 or organic solvent)

Special Issue Information

Dear Colleagues,

It is our pleasure to invite you to contribute to this Special Issue of Catalysts, entitled “Biotransformations Catalyzed by Immobilized Enzymes”.

Biotransformations catalyzed by immobilized enzymes represent a fascinating research and development area. From studies in the laboratory via pilot scale-up to successfully implemented large- or very large-scale production in food, pharmaceutical, biofuel, and biodegradable plastics, immobilized enzymes catalyze a broad range of reactions.

Regardless of the immobilization strategy used, the targeted advantages of immobilization are:

(i)  Easy recovery/separation of the biocatalyst from the reaction mixture;

(ii)  Easy recycling through multiple runs;

(iii)  Improved stability (and sometimes activity) versus process parameters, such as temperature or pH;

(iv) Continuous flow reactors such as packed bed reactors in order to suppress inhibition of the enzyme by the reaction product(s) while getting full conversion and pure products in cases of equimolar ratio of substrates and where appropriate process conditions are used.

Combining these four advantages, region-, chemo- or enantio-selectivity of the immobilized enzymes can lead to single successful transformation or, even better, cascade biotransformation processes.

We therefore invite you to submit your current work in this area, but also in the adjacent fields such as:

(i)  Biotransformations catalyzed by immobilized enzymes in anhydrous solvent (organic, supercritical, eutectic, ionic);

(ii)  Use and up-scalability in a reactor and/or recyclability;

(iii) Process intensification involving immobilized enzymes;

(iv) Production cost and eco-compatibility (lifecycle assessments, etc.).

In this Special Issue, we welcome contributions from all aspects of biotransformations catalyzed by immobilized enzymes. The following keywords are a guideline: enzyme immobilization, enzyme recycling, enzyme carrier interaction, continuous reactions, biocatalytic cascades, non-aqueous reaction systems, downstream processing, lifecycle assessment.

We look forward to your contributions to this interesting field.

Prof. Dr. Ulf Hanefeld
Dr. Yann P. Guiavarc'h
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Catalysts is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Enzyme immobilization
  • Enzyme recycling
  • Enzyme carrier interaction
  • Continuous reactions
  • Biocatalytic cascades
  • Non-aqueous reaction systems
  • Downstream processing
  • Lifecycle assessment

Published Papers

This special issue is now open for submission, see below for planned papers.

Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: Immobilisation of GtNL for the Henry reaction
Authors: Jose Coloma Hurel; Peter-Leon Hagedoorn; Ulf Hanefeld
Affiliation: Biocatalysis & Organic Chemistry, Delft University of Technology, Delft, The Netherlands

Title: O-acylation of cannabidiol with immobilized lipases in a continuous packed bed reactor using supercritcal CO2 as green solvent
Authors: Yann P. Guiavarc'h
Affiliation: 1. University of Lorraine (UL), Nancy, France; 2. The Reactions and Chemical Engineering Laboratory (LRGP), joint unit of CNRS (National Center for Scientific Research) and UL, team “Bioprocesses-Biomolecules”, Nancy, France

Title: Continuous production of antioxydant peptides from selective globulin proteolysis in a membrane enzymatic reactor
Authors: Nastassia Kaugarenia; Romain Kapel; Sophie Beaubier
Affiliation: Laboratoire Réactions et Génie des Procédés (LRGP), Nancy, France

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