Enzyme Design, Engineering and Applications in Efficient Biocatalysis
A special issue of Catalysts (ISSN 2073-4344). This special issue belongs to the section "Biocatalysis".
Deadline for manuscript submissions: 31 July 2026 | Viewed by 624
Special Issue Editors
Interests: enzyme design; biocatalysis; synthetic biology; pharmaceutical and biomanufacturing
Special Issue Information
Dear Colleagues,
Enzyme design and engineering have emerged as transformative drivers in efficient biocatalysis, revolutionizing the landscape of sustainable chemical synthesis. Notably, the precise modulation of enzyme structure and function–enabled by advances in (semi) rational and computational design–has overcome inherent limitations such as poor stability, narrow substrate scope, and low catalytic efficiency, unlocking vast industrial potential. To date, thousands of engineered enzymes have been developed for diverse catalytic reactions, and the field continues to expand at an accelerating pace, standing as one of the most vibrant and impactful areas in modern biotechnology.
Efficient biocatalysis plays an increasingly indispensable role in green manufacturing, offering remarkable advantages, including high chemo-, regio-, and enantioselectivity, mild reaction conditions, and minimal environmental footprint, compared to traditional chemical catalysis. Over the past two decades, engineered enzymes have been widely applied in key sectors such as pharmaceutical synthesis, fine chemical production, food processing, and bioremediation. The inherent sustainability, recyclability, and specificity of engineered enzymes make them superior catalysts for addressing global challenges in sustainable development.
This Special Issue covers all aspects of enzyme-related biocatalysis, including enzyme design principles, engineering methodologies, structural–functional characterization, and practical applications in molecular transformations. Both original research articles reporting novel findings and comprehensive review papers/perspectives summarizing cutting-edge progress in the field are warmly welcome.
The primary area of focus spans a broad spectrum of interdisciplinary research, centering on the integration of enzyme design, engineering, and efficient biocatalysis to address real-world challenges in sustainable production and biotechnology.
Prof. Dr. Xiaoling Tang
Dr. Xue Cai
Guest Editors
Manuscript Submission Information
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Keywords
- enzyme design
- biocatalysis
- synthetic biology
- pharmaceutical and biomanufacturing
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