Mass Sensitive Biosensors for Biomedical Applications
A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Nano- and Micro-Technologies in Biosensors".
Deadline for manuscript submissions: 30 June 2026 | Viewed by 655
Special Issue Editors
Interests: biosensors; DNA aptamers; electrochemistry; molecular acoustics; model membranes; nanomaterials; nanoparticles
Special Issues, Collections and Topics in MDPI journals
Interests: acoustic wave sensors; physiological measurements in vivo; microelectrodes; theranostics; surface chemistries; biosensors
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Mass-sensing devices operate generally on the principles of acoustic wave physics associated with piezoelectric materials. Like many biosensors, these sensors operate based on a probe deposited on the device, which is allowed to interact with a target species in a sample solution. Although a number of sensors are available based on various wave motions, two major types have been employed for bio-detection—surface acoustic wave (SAW) and thickness shear mode (TSM) devices. The former function by instigating acoustic waves using interdigital transducers (IDTs), whereas TSM devices involve bulk waves generated by conventional electrodes. The notion of mass sensitivity has its origin in the iconic Sauerbrey expression, which correlates the resonance frequency of the sensor’s piezoelectric material with mass deposited on the device’s surface. Over the years, this has spawned the term “quartz crustal microbalance”, at least for TSM sensors. However, we have recently recognized that acoustic wave biosensors respond not only to mass loading but also to material surface changes in the device, such as interfacial free energy, electrical charge, and viscoelasticity. These observations open up possibilities for the development of novel and highly sensitive reposes to target molecules, as well as for investigating new aspects of surface chemistry.
Prof. Dr. Tibor Hianik
Prof. Dr. Michael Thompson
Guest Editors
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Keywords
- piezoelectric acoustic wave sensors
- surface acoustic wave devices
- thickness shear mode biosensor
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