Special Issue "Trends in Optical Biosensing and Bioimaging"

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Optical and Photonic Biosensors".

Deadline for manuscript submissions: 31 July 2023 | Viewed by 1937

Special Issue Editor

Massachusetts Institute of Technology, Cambridge, MA, USA
Interests: biomedical spectroscopy; microscopy; endoscopy; optical diagnosis and therapeutics monitoring; molecular probe
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In recent decades, fast-growing semiconductor and nanofabrication technologies combined with machine-learning algorithms have significantly advanced the field of optical sensing and imaging.

Bulky and expensive laser systems evolved into compact and inexpensive systems with less power consumption. Sophisticated but robust turn-key CW and pulsed-laser systems are the key components of portable clinical instruments and successful translation. Highly efficient electric detectors/cameras are widely used. Specifically, compact camera modules with decent performance are available at low cost due to the smartphone industry. Advanced nanotechnology brought new tools to the field. High-performance optical filters are used to exclude unwanted photons in many optical systems. Nanoparticles are designed for molecular imaging and nanostructures are used to target specific molecules. Optical fiber technology enabled measuring in vivo signals from tissue locations that are not easily accessible by traditional imaging systems. More recently, machine-learning algorithms were actively introduced to the optics field, allowing the extraction of maximum information from existing or new data. Furthermore, these algorithms help in developing low-cost devices as they ease hardware requirements.

This Special Issue is focused on the recent advances in optical biosensing and bioimaging as well as advanced algorithms. You are invited to submit your original articles or reviews.

Dr. Jeon Woong Kang
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomedical spectroscopy
  • microscopy
  • endoscopy
  • optical diagnosis and therapeutics monitoring
  • molecular probe
  • machine learning
  • artificial intelligence

Published Papers (1 paper)

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Research

Article
Spectral Multiplexing of Fluorescent Endoscopy for Simultaneous Imaging with Multiple Fluorophores and Multiple Fields of View
Biosensors 2023, 13(1), 33; https://doi.org/10.3390/bios13010033 - 27 Dec 2022
Viewed by 1407
Abstract
Complex clinical procedures and small-animal research procedures can benefit from dual-site imaging provided by multiple endoscopic devices. Here, an endoscopic system is proposed which enables multiple fluorescence microendoscopes to be spectrally multiplexed on a single microscope base, enabling light sources and optical relays [...] Read more.
Complex clinical procedures and small-animal research procedures can benefit from dual-site imaging provided by multiple endoscopic devices. Here, an endoscopic system is proposed which enables multiple fluorescence microendoscopes to be spectrally multiplexed on a single microscope base, enabling light sources and optical relays to be shared between endoscopes. The presented system is characterized for resolution using USAF-1951 resolution test charts and for modulation transfer function using the slanted edge method. Imaging is demonstrated both directly and with microendoscopes attached. Imaging of phantoms was demonstrated by targeting USAF charts and fiber tissues dyed for FITC and Texas Red fluorescence. Afterwards, simultaneous liver and kidney imaging was demonstrated in mice expressing mitochondrial Dendra2 and injected with Texas Red-dextran. The results indicate that the system achieves high channel isolation and submicron and subcellular resolution, with resolution limited by the endoscopic probe and by physiological movement during endoscopic imaging. Multi-channel microendoscopy provides a potentially low-cost means of simultaneous multiple endoscopic imaging during biological experiments, resulting in reduced animal harm and potentially increasing insight into temporal connections between connected biological systems. Full article
(This article belongs to the Special Issue Trends in Optical Biosensing and Bioimaging)
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