Metabolic Aspects of Myelinating Glia

Dear Colleagues,

Myelinating cells surround axons of the central (CNS) and peripheral (PNS) nervous systems and produce the myelin sheath to accelerate the propagation of action potentials, to support axonal health, and to refine neural circuits. Myelination is a metabolically demanding process. Findings from studies of axon-glial interactions indicate a crucial role of glial cells in the metabolic support of axon that is independent of myelination itself. In this Special Issue on metabolic aspects of myelinating glia, we plan to include work that provides novel insights into the metabolism of myelinating glia in health and disease. Glial metabolism includes the contribution of myelin itself, due to its high lipid content, to provide white matter energy balance and axonal metabolic support.  Due to this energy consuming process and the associated high metabolic turnover, oligodendrocytes, the myelinating glia of the CNS, are vulnerable to cytotoxic and excitotoxic factors. Energy requirements on other glial cells that are known to interact with oligodendrocytes/Schwann cells and influence their development and function, such as astrocytes and microglia, are also going to be included. Specific molecular pathways such as mTOR, myelinophagy, fatty-acid oxidation and other mechanisms will be discussed. Manipulation and alterations of these and other relevant pathways will be discussed, since they may underlie different types of degenerative pathologies. Finally, the opportunity to use myelinating glia-axon metabolic interactions as therapeutic targets to treat CNS and PNS degenerative disorders will also be addressed.

Prof. Dr. Domna Karagogeos
Prof. Dr. Kleopas A. Kleopa
Guest Editors

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• oligodendrocytes
• Schwann cells
• myelin
• mTOR
• autophagy
• fatty acids
• glia-axon interactions
• mitochondrial metabolism
• multiple sclerosis
• leukodystrophy
• peripheral neuropathies