Advances in Ion-Transporting Proteins
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Cellular Biochemistry".
Deadline for manuscript submissions: closed (31 January 2021) | Viewed by 248
Special Issue Editors
Interests: ion-transporting proteins; transportsome structure and function in gastrointestinal cells; molecular identification of volume-regulated anion channel; physiological functions of transient receptor potential channel
Special Issue Information
Dear Colleagues,
Asymmetric distribution of ions across the membrane is essential for maintaining the cell homeostasis and survival. The asymmetry is achieved by ion transporting proteins, including channels, transporters, and pumps, in the cell membrane. In some cases, functional relations between different proteins are important to elicit normal transporting function. Functional disorders of ion transporting proteins are closely related to various diseases. Actually, ion transport proteins have been recognized as important drug targets. Cryo-electron microscopy (or X-ray crystallography) is one of advanced approaches to drug discovery for ion transporting proteins. Recent studies of omics analyses, metabolomics, and biomarkers are also significant.
In this Special Issue, we would like to focus on recent progress in molecular mechanisms, and the physiological relevance of ion-transporting proteins studied via structural, biophysical, biological, physiological, pathophysiological, and pharmacological techniques. We would also like to discuss how these studies can be applied for actual drug development and clinical use.
Prof. Dr. Hideki Sakai
Dr. Takahiro Shimizu
Guest Editors
Manuscript Submission Information
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Keywords
- channel
- transporter
- pump
- drug discovery
- structure and function
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