Advance in Hippo Signaling Pathway in Cancer Therapy
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Medicine".
Deadline for manuscript submissions: closed (10 September 2021) | Viewed by 295
Special Issue Editors
Interests: inflammatory signaling mechanisms; cancer; immune response; diagnosis and treatment markers; new targeted drugs
Special Issue Information
Dear Colleagues,
The Hippo signaling is required for the regulation of organ size, tissue homeostasis and immune response. Dysregulations of the Hippo pathway are commonly found in various diseases including malignant tumors. Therefore, better understanding of this pathway is needed for not only deciphering the nature of tissue homeostasis and organ size control, but also for developing new therapeutic strategies and precise medicine. Over the last decade, great progresses have been achieved regarding the physiological and pathological roles of Hippo pathway. However, the mechanisms of initiating and/or sensing extracellular signals by the Hippo pathway in a context of cell-cell communications are still elusive; how these signals are transduced and then integrated with metabolic and epigenetic cues to ensure concerted cell growth (size) and proliferation (number) in a given organ are poorly understood.
The scope of this research topic is to gather a comprehensive list of articles related to molecular dissection and translational investigation of both Hippo pathway and its co-regulation with metabolism and epigenetics. The research topic will cover various aspects of Hippo pathway ranging from tissue homeostasis and organ regeneration to tumorigenesis and immune responses, as well as development of novel cancer therapeutics by targeting Hippo pathway.
Prof. Zhaocai Zhou
Guest Editor
Dr. Shi Jiao
Co-Guest Editor
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Keywords
- Hippo/YAP signaling pathway
- Tissue homeostasis
- Organ size control
- Metabolic program
- Epigenetic regulation
- Therapeutic intervention
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