Advances in Computational Structural Biology
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Bioinformatics and Systems Biology".
Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 366
Special Issue Editor
Special Issue Information
Dear Colleagues,
Nucleic acids encode the information of life, while proteins support the activity of all lives. Proteins are the functional unit of biological systems, and their functions are determined by their structures. If the structure of a protein can be solved, we may identify its activities, study its interactions with other molecules, and modify its properties. Because of the high cost of solving structures, computational protein structure prediction (PSP) has long been a dream of scientists. Given accurate PSP, efficient drug design, protein engineering, and biomaterial developments will all be achievable. Due to the advances in protein sequencing, there have been 277 billion known sequences, exceeding the number of known structures over a thousand folds. Artificial intelligence techniques are quickly evolving, and their application in PSP is astonishing. AlphaFold2, the PSP algorithm developed by Google DeepMind, has achieved ~87% accuracy in 2020, almost fulfilling our 50-year-old dream. DeepMind has predicted all human proteins and is predicting all known sequences. The amount of accurately predicted structures is about to grow explosively, opening numerous new scientific and business opportunities. Computational protein structural big data analyses will undoubtedly play critical roles in the coming new era.
This Special Issue welcomes original research papers, comprehensive reviews, and short communications focusing on the latest developments and practical applications of computational protein structural biology. Every submission will undergo a rapid, fair, and professional peer-review process.
Prof. Dr. Wei-Cheng Lo
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.
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