Special Issue "Immunoconjugates"
A special issue of Biomedicines (ISSN 2227-9059).
Deadline for manuscript submissions: closed (31 December 2017).
Interests: immunotoxin; immunoconjugate; ribosome-inactivating proteins
Special Issues and Collections in MDPI journals
The immunoconjugate concept is inspired by Paul Ehrlich’s magic bullet idea, and consists in the linking of a pharmacologically-active molecule to a carrier for selective delivery to target cells. Immunoconjugates could be used to eliminate unwanted cells that are responsible for pathological conditions, but are primarily applied in the field of experimental cancer therapy. The response rates observed in clinical trials have often been greater than those reported for conventional antiblastic drugs, and new and exciting opportunities for controlled drug delivery and release have been developed. Antibodies are the most utilized carriers due to their stability in blood and avidity and affinity for their target antigen. As toxic moiety, different active substances have been used, such as drugs, human enzymes, and toxins (both bacterial and plant).
In this Special Issue, I am aiming to focus on recent developments in the chemistry, pharmacology and medical implications of antibody-based immunoconjugates for experimental therapy of cancer and other diseases. I, therefore, take pleasure in inviting colleagues to contribute with their valuable work to this Special Issue in Biomedicines.
Dr. Letizia Polito
Manuscript Submission Information
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