Special Issue "Immunoconjugates"

A special issue of Biomedicines (ISSN 2227-9059).

Deadline for manuscript submissions: closed (31 December 2017).

Special Issue Editor

Dr. Letizia Polito
Website
Guest Editor
Department of Experimental, Diagnostic and Specialty Medicine-DIMES; Alma Mater Studiorum, University of Bologna, Via San Giacomo 14, 40126 Bologna, Italy
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Special Issue Information

Dear Colleagues,

The immunoconjugate concept is inspired by Paul Ehrlich’s magic bullet idea, and consists in the linking of a pharmacologically-active molecule to a carrier for selective delivery to target cells. Immunoconjugates could be used to eliminate unwanted cells that are responsible for pathological conditions, but are primarily applied in the field of experimental cancer therapy. The response rates observed in clinical trials have often been greater than those reported for conventional antiblastic drugs, and new and exciting opportunities for controlled drug delivery and release have been developed. Antibodies are the most utilized carriers due to their stability in blood and avidity and affinity for their target antigen. As toxic moiety, different active substances have been used, such as drugs, human enzymes, and toxins (both bacterial and plant).

In this Special Issue, I am aiming to focus on recent developments in the chemistry, pharmacology and medical implications of antibody-based immunoconjugates for experimental therapy of cancer and other diseases. I, therefore, take pleasure in inviting colleagues to contribute with their valuable work to this Special Issue in Biomedicines.

Dr. Letizia Polito
Guest Editor

Manuscript Submission Information

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Published Papers (2 papers)

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Open AccessReview
Immunoconjugates for Osteosarcoma Therapy: Preclinical Experiences and Future Perspectives
Biomedicines 2018, 6(1), 19; https://doi.org/10.3390/biomedicines6010019 - 10 Feb 2018
Cited by 8
Abstract
Osteosarcoma (OS) is an aggressive osteoid-producing tumor of mesenchymal origin, which represents the most common primary bone malignancy. It is characterized by a complex and frequently uncertain etiology. The current standard care for high-grade OS treatment is neoadjuvant chemotherapy, followed by surgery and [...] Read more.
Osteosarcoma (OS) is an aggressive osteoid-producing tumor of mesenchymal origin, which represents the most common primary bone malignancy. It is characterized by a complex and frequently uncertain etiology. The current standard care for high-grade OS treatment is neoadjuvant chemotherapy, followed by surgery and post-operative chemotherapy. In order to ameliorate survival rates of patients, new therapeutic approaches have been evaluated, mainly immunotherapy with antibody-drug conjugates or immunoconjugates. These molecules consist of a carrier (frequently an antibody) joined by a linker to a toxic moiety (drug, radionuclide, or toxin). Although several clinical trials with immunoconjugates have been conducted, mainly in hematological tumors, their potential as therapeutic agents is relatively under-explored in many types of cancer. In this review, we report the immunoconjugates directed against OS surface antigens, considering the in vitro and in vivo studies. To date, several attempts have been made in preclinical settings, reporting encouraging results and demonstrating the validity of the idea. The clinical experience with glembatumumab vedotin may provide new insights into the real efficacy of antibody-drug conjugates for OS therapy, possibly giving more information about patient selection. Moreover, new opportunities could arise from the ongoing clinical trials in OS patients with unconjugated antibodies that could represent future candidates as carrier moieties of immunoconjugates. Full article
(This article belongs to the Special Issue Immunoconjugates)
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Open AccessReview
Site-Specific Antibody Conjugation for ADC and Beyond
Biomedicines 2017, 5(4), 64; https://doi.org/10.3390/biomedicines5040064 - 09 Nov 2017
Cited by 18
Abstract
Antibody-drug conjugates (ADCs) have become a promising class of antitumor agents with four conjugates being approved by regulatory agencies for treating cancer patients. To improve the conventional conjugations that are currently applied to generate these heterogeneous products, various site-specific approaches have been developed. [...] Read more.
Antibody-drug conjugates (ADCs) have become a promising class of antitumor agents with four conjugates being approved by regulatory agencies for treating cancer patients. To improve the conventional conjugations that are currently applied to generate these heterogeneous products, various site-specific approaches have been developed. These methods couple cytotoxins or chemotherapeutic drugs to specifically defined sites in antibody molecules including cysteine, glutamine, unnatural amino acids, short peptide tags, and glycans. The ADCs produced showed high homogeneity, increased therapeutic index, and strong antitumor activities in vitro and in vivo. Moreover, there are recent trends in using these next generation technologies beyond the cytotoxin-conjugated ADC. These site-specific conjugations have been applied for the generation of many different immunoconjugates including bispecific Fab or small molecule–antibody conjugates, immunosuppressive antibodies, and antibody–antibiotic conjugates. Thus, it is likely that additional technologies and related site-specific conjugates will emerge in the near future, with various chemicals or small molecular weight proteins in addition to cytotoxin for better treatment of many challenging diseases. Full article
(This article belongs to the Special Issue Immunoconjugates)
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