Extracellular Vesicles as Future Therapeutics and Indicators of Cardiac Disease
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".
Deadline for manuscript submissions: closed (30 September 2023) | Viewed by 4208
Special Issue Editors
Interests: ischemic heart disease; myocardial infarction; cardiac regeneration; extracellular vesicles; exosomes; modified mRNA
Interests: myocardial infarction; extracellular vesicles; stem cell biology; cardiovascular diseases; translational medicine
Special Issue Information
Dear Colleagues,
Cardiovascular diseases (CVDs) are the leading cause of mortality and morbidity worldwide. Although extensive research and studies have been carried out to improve the treatment and prognosis of CVDs, current treatment and diagnostic strategies are not satisfying. Extracellular vesicles have attracted significant attention in mediating intercellular communication during cardiovascular development and pathophysiology. Exosomal ncRNAs, including microRNAs, lncRNAs, and circRNAs, are considered to be key players, offering a potential source of novel diagnostic and prognostic biomarkers for CVDs. Stem-cell-derived exosomes can be used as a novel alternative to cell therapies in cardiovascular disease owing to their biocompatibility and non-immunogenicity. However, hurdles regarding exosome purification, batch difference, dosage, and untargeted delivery need to be overcome in preclinical and clinical practice.
This Special Issue aims to highlight the novel studies and strategies that might overcome current obstacles in cardiovascular translational medicine and their potential applications. Original research and review articles are welcome.
Specific themes we would like contributors to address include, but are not limited to:
- Extracellular vesicles in cardiac cells differentiation;
- Extracellular vesicles in cardiovascular repair and regeneration;
- Extracellular vesicles in cardiovascular protection;
- Extracellular vesicles in cardiovascular drug development and safety assay;
- Extracellular vesicles in tissue engineering;
- Extracellular vesicles in CVD diagnostic and prognostic;
- Extracellular vesicles in CVD pathogenesis;
- Extracellular vesicles in cardiovascular homeostasis.
Dr. Jiacheng Sun
Dr. Junjie Yang
Dr. Yu-An Lu
Guest Editors
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Keywords
- cardiovascular disease
- ncRNA
- extracellular vesicles
- cardiac regeneration
- diagnostics
- therapeutics
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