Advancements in Understanding and Treating Oral Pathologies: From Dry Mouth to Oral Cancer—2nd Edition

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cell Biology and Pathology".

Deadline for manuscript submissions: 31 December 2026 | Viewed by 1007

Special Issue Editors


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Guest Editor
Laboratory of Histology-Embryology, Molecular Carcinogenesis Group, University of Athens, Athens, Greece
Interests: oral inflammatory conditions; oral cancer and precancerous conditions; cellular senescence and its impact on human disease
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Oral Medicine Medical School, University of Athens, Athens, Greece
Interests: oral cancer; oral disease
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue explores various aspects of the pathogenesis of oral diseases, emphasizing therapeutic interventions rooted in pathogenicity and providing examples that showcase the ways in which the pathogenesis of specific oral conditions reflects the interconnected nature of oral and general health. The central goal aligns with the World Health Organization’s objective for promoting oral health, as outlined in the 2021 Resolution. Recent advancements in understanding and treating oral pathologies, ranging from common issues such as dry mouth (xerostomia) and taste disorders (dysgeusia) to severe conditions such as oral cancer and precancerous lesions, constitute the core focus. The Special Issue examines not only the therapeutic aspects but also the geographical, virological, and environmental dimensions of pathogenesis. This broader perspective incorporates recommendations regarding environmental, genetic, and social factors, aiming to provide a more comprehensive and understandable view of the subject. Additionally, dental treatments can offer valuable insights into general pathology, showcasing the interdisciplinary nature of oral healthcare. The Special Issue invites original research articles, reviews, and case reports that contribute valuable insights to the broader knowledge base in these fields.

Dr. Eleni Georgakopoulou
Dr. George Laskaris
Guest Editors

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Keywords

  • oral pathologies
  • oral diseases
  • pathogenesis
  • therapeutic interventions
  • interdisciplinary nature of oral healthcare
  • xerostomia
  • dysgeusia
  • oral cancer
  • precancerous lesions
  • oral inflammatory conditions

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Published Papers (1 paper)

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Research

16 pages, 3287 KB  
Article
Clinical and Radiological Evaluation of Oral and Maxillofacial Status in Patients Undergoing Antiresorptive Therapy and Its Relationship with MRONJ
by Marcela Wiltgen Jeffman, Valesca Sander Koth, Fernanda Gonçalves Salum, Maria Ivete Rockenbach, Aline Cantarelli Morosolli and Karen Cherubini
Biomedicines 2025, 13(12), 3054; https://doi.org/10.3390/biomedicines13123054 - 11 Dec 2025
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Abstract
Background/Objectives: Patients undergoing antiresorptive therapy were evaluated, focusing on clinical and radiological features and their relationship with medication-related osteonecrosis of the jaw (MRONJ). Methods: Patients were allocated to two groups: MRONJ (n = 27) and non-MRONJ (n = 139). [...] Read more.
Background/Objectives: Patients undergoing antiresorptive therapy were evaluated, focusing on clinical and radiological features and their relationship with medication-related osteonecrosis of the jaw (MRONJ). Methods: Patients were allocated to two groups: MRONJ (n = 27) and non-MRONJ (n = 139). Clinical evaluation included decayed, missing, and filled teeth (DMFT), number of teeth, periodontal status, prosthesis use, and preventive/therapeutic measures. Imaging analysis included panoramic radiography (PAN) and cone beam computerized tomography (CBCT) to assess MRONJ-related signs. Results: The sample showed high levels of DMFT and prosthesis use. There was a tendency of higher prevalence of deeper periodontal pockets in the MRONJ group, with greater need for oral hygiene reinforcement and chlorhexidine prescription. PAN showed higher frequency of osteolysis, persistent alveolar socket, bone sequestration, mandibular canal involvement, periosteal reaction, and sinus involvement in the MRONJ group. Still on PAN, all cases in both groups exhibited a sclerotic trabecular bone pattern. CBCT showed higher frequency of a sclerotic trabecular bone pattern, mandibular canal involvement, and bone sequestration in the MRONJ group. Composite radiographic index modified (CRIm) was higher in the MRONJ group for PAN and CBCT, with low-grade cases in the non-MRONJ and medium-/high-grade cases in the MRONJ group. A positive correlation was found between CRIm and MRONJ staging. Conclusions: This study underscores the role of preventive oral care in patients undergoing antiresorptive therapy, highlighting the need for regular periodontal monitoring. Also emphasized is the importance of integrating clinical and radiographic examinations of these patients. Accordingly, CRIm seems to be a reliable tool for MRONJ staging and monitoring. Full article
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