The Interplay Between miRNA and Mitochondrial Dysfunction in Neurodegenerative Diseases
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Neurobiology and Clinical Neuroscience".
Deadline for manuscript submissions: closed (30 November 2025) | Viewed by 2338
Editor
Interests: neurodegenerative disease; aging; traumatic brain injury; neuroprotection; neurorepair; neuroprotective agents
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
We are pleased to present a new Special Issue entitled “The Interplay Between miRNA and Mitochondrial Dysfunction in Neurodegenerative Diseases”.
MicroRNAs (miRNAs) are small non-coding RNAs that play a pivotal role in post-transcriptional gene regulation. They are involved in nearly every aspect of fundamental physiological and pathological cellular functions. Over the past decade, our understanding of miRNA biology, their target genes, biomarkers, and potential therapeutic applications has significantly increased. The role of nuclear DNA-encoded miRNAs in the progression of various neurological diseases, such as Parkinson’s disease, Alzheimer’s disease, and Huntington’s disease, is well established.
However, our knowledge about mitochondrial miRNAs remains limited. These miRNAs either originate from the mitochondrial genome or are directly translocated into the mitochondria. In this context, emerging evidence suggests a potential interplay between mitochondrial dysfunction and miRNA in the progression of various neurodegenerative diseases.
This Special Issue welcomes contributions that expand our understanding of gene expression regulation by either nuclear DNA-encoded microRNAs and/or mitochondrial miRNAs in neurodegenerative diseases, and the involvement of mitochondrial dysfunctions in these pathologies.
We look forward to receiving submissions from outstanding experts in the field.
Dr. Mariano Catanesi
Guest Editor
Manuscript Submission Information
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Keywords
- miRNA
- neurodegenerative diseases
- mitochondrial dysfunction
- aging
- gene expression
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