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Biomedicines
Special Issues
Macrophages in Cardio-Renal Diseases
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Macrophages in Cardio-Renal Diseases

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Endocrinology and Metabolism Research".

Deadline for manuscript submissions: closed (30 April 2024) | Viewed by 4759

Special Issue Editors

Dr. Satyesh K. Sinha

E-Mail Website
Guest Editor
1. Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
2. Department of Internal Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, CA 90059, USA
Interests: cardiovascular disease; diabetic nephropathy; atherosclerosis; inflammation; macrophage
Special Issues, Collections and Topics in MDPI journals
Dr. Yuchen Wang

E-Mail Website
Guest Editor
Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, CA 90095, USA
Interests: immune microenvironment; cell-cell communication; inflammation and bioinformatics

Special Issue Information

Dear Colleagues,

Macrophages play a significant role in cardio-renal diseases, including atherosclerosis, heart failure, hypertension, and chronic kidney disease. They contribute to the development and progression of these conditions through inflammation, tissue remodeling, and fibrosis. In atherosclerosis, macrophages form lipid-laden foam cells within arterial walls, thus leading to plaque formation. They promote myocardial inflammation and fibroblast activation, contributing to adverse remodeling in heart failure. Macrophages also play a role in hypertension by causing renal inflammation and vascular dysfunction. In chronic kidney disease, macrophages contribute to renal inflammation, fibrotic remodeling, and impaired tissue repair. Targeting macrophage activities and interactions holds promise for therapeutic interventions in cardio-renal diseases, offering opportunities to mitigate inflammation, improve vascular function, and preserve renal integrity. Therefore, this issue will focus on recent findings uncovering new aspects of macrophage biology in cardio-renal diseases.

Dr. Satyesh K. Sinha
Dr. Yuchen Wang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cardiovascular disease and macrophages
  • macrophage-mediated inflammation
  • macrophage phenotypes
  • macrophage senescence
  • macrophage proliferation and survival
  • macrophages and lipid metabolism

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Published Papers (2 papers)

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Review

21 pages, 2115 KiB  
Review
Fiery Connections: Macrophage-Mediated Inflammation, the Journey from Obesity to Type 2 Diabetes Mellitus and Diabetic Kidney Disease
by Satyesh K. Sinha, Maria Beatriz Carpio and Susanne B. Nicholas
Biomedicines 2024, 12(10), 2209; https://doi.org/10.3390/biomedicines12102209 - 27 Sep 2024
Viewed by 2073
Abstract
The high prevalence of diabetes mellitus (DM) poses a significant public health challenge, with diabetic kidney disease (DKD) as one of its most serious consequences. It has become increasingly clear that type 2 DM (T2D) and the complications of DKD are not purely [...] Read more.
The high prevalence of diabetes mellitus (DM) poses a significant public health challenge, with diabetic kidney disease (DKD) as one of its most serious consequences. It has become increasingly clear that type 2 DM (T2D) and the complications of DKD are not purely metabolic disorders. This review outlines emerging evidence related to the step-by-step contribution of macrophages to the development and progression of DKD in individuals who specifically develop T2D as a result of obesity. The macrophage is a prominent inflammatory cell that contributes to obesity, where adipocyte hypertrophy leads to macrophage recruitment and eventually to the expansion of adipose tissue. The recruited macrophages secrete proinflammatory cytokines, which cause systemic inflammation, glucose dysregulation, and insulin sensitivity, ultimately contributing to the development of T2D. Under such pathological changes, the kidney is susceptible to elevated glucose and thereby activates signaling pathways that ultimately drive monocyte recruitment. In particular, the early recruitment of proinflammatory macrophages in the diabetic kidney produces inflammatory cytokines/chemokines that contribute to inflammation and tissue damage associated with DKD pathology. Macrophage activation and recruitment are crucial inciting factors that also persist as DKD progresses. Thus, targeting macrophage activation and function could be a promising therapeutic approach, potentially offering significant benefits for managing DKD at all stages of progression. Full article
(This article belongs to the Special Issue Macrophages in Cardio-Renal Diseases)
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25 pages, 2874 KiB  
Review
The Multifaceted Nature of Macrophages in Cardiovascular Disease
by Cindy X. Li and Lixia Yue
Biomedicines 2024, 12(6), 1317; https://doi.org/10.3390/biomedicines12061317 - 13 Jun 2024
Cited by 4 | Viewed by 2098
Abstract
As the leading cause of mortality worldwide, cardiovascular disease (CVD) represents a variety of heart diseases and vascular disorders, including atherosclerosis, aneurysm, ischemic injury in the heart and brain, arrythmias, and heart failure. Macrophages, a diverse population of immune cells that can promote [...] Read more.
As the leading cause of mortality worldwide, cardiovascular disease (CVD) represents a variety of heart diseases and vascular disorders, including atherosclerosis, aneurysm, ischemic injury in the heart and brain, arrythmias, and heart failure. Macrophages, a diverse population of immune cells that can promote or suppress inflammation, have been increasingly recognized as a key regulator in various processes in both healthy and disease states. In healthy conditions, these cells promote the proper clearance of cellular debris, dead and dying cells, and provide a strong innate immune barrier to foreign pathogens. However, macrophages can play a detrimental role in the progression of disease as well, particularly those inflammatory in nature. This review will focus on the current knowledge regarding the role of macrophages in cardiovascular diseases. Full article
(This article belongs to the Special Issue Macrophages in Cardio-Renal Diseases)
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