Potential Off-Target Actions of Small-Molecule Modulators Initially Designed for Special Functions

Dear Colleagues,

Many drugs and compounds primarily target the cytoplasm or nucleus of cells. By acting on these target sites (such as tyrosine kinase), they regulate various cellular functions, such as inhibiting apoptosis, restraining cell growth, and suppressing ferroptosis. However, it needs to be mentioned that before these substances can enter the cell, they must interact with the surface membrane, particularly the ion channels on the cell membrane. Voltage-gated ion channels with different gating kinetics have unique biophysical and pharmacological characteristics. These substances are therefore very likely to interact with these ion channels, potentially synergizing or causing specific effects in conjunction with their originally intended targets, and even leading to other adverse effects, such as cardiac arrhythmias. Therefore, it is deeply hoped that investigators who are interested in this field will contribute their findings to this Special Issue, facilitating the exchange of knowledge between basic and clinical academia.

Prof. Dr. Sheng-Nan Wu
Guest Editor

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• small-molecule modulators
• off-target effects
• ion channel modulation
• pharmacological impact