Anti-Cancer Agents: Synthesis and Evaluation of Pharmacological Activity
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Drug Discovery, Development and Delivery".
Deadline for manuscript submissions: 28 February 2026 | Viewed by 12
Special Issue Editor
Special Issue Information
Dear Colleagues,
The search for effective and selective anticancer agents remains a primary challenge in drug discovery and development. Chemotherapy, a mainstay in cancer treatment, often suffers from drawbacks such as poor selectivity, drug resistance, and severe side effects. As such, there is a growing need to develop novel compounds that can efficiently target cancer cells while sparing normal tissues.
This Special Issue focuses on the synthesis, characterization, and pharmacological evaluation of new anticancer agents, emphasizing small molecules, natural products, metal complexes, and hybrid compounds. The contributions aim to showcase the latest progress in designing compounds with enhanced antiproliferative activity, reduced toxicity, and improved selectivity against various cancer types.
The studies reflect a multidisciplinary approach, encompassing organic and medicinal chemistry, computational drug design, structure–activity relationship (SAR) investigations, and in vitro and in vivo testing. This collection highlights strategies to target key signaling cascades, inhibit enzyme activity, induce apoptosis, or interfere with the cell cycle in tumor cells. Furthermore, it underscores the potential of structure modifications to maximize potency while minimizing side effects.
Together, these investigations underscore the significance of rational drug design and extensive biological evaluation in developing effective anticancer agents. This Special Issue aims to provide important insights and foster future innovations in the field of anticancer drug discovery.
Dr. Sureshbabu Popuri
Guest Editor
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Keywords
- anticancer agents
- synthesis
- pharmacological evaluation
- medicinal chemistry
- small molecules
- metal complexes
- structure–activity relationship (SAR)
- cytotoxic activity
- apoptosis
- drug discovery
- chemotherapy
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