Tumor Microenvironment in Cancer: Basic Science, Artificial Intelligence, and Clinical Research
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cancer Biology and Oncology".
Deadline for manuscript submissions: 31 October 2025 | Viewed by 52
Special Issue Editor
Interests: lymphoma; tumor microenvironment; immunotherapy; artificial intelligence
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The tumor microenvironment (TME) is a critical determinant of cancer progression, therapy resistance, and immune evasion, making it a key focus for innovative treatment strategies. Achieving a complete response remains challenging due to the persistence of drug-resistant clones supported by the TME and the multiple resistance mechanisms through which the TME counteracts therapy efficacy. The dynamic interactions between cancer stem cells, stromal components, immune infiltrates, and the extracellular matrix (ECM) create a highly adaptive and heterogeneous ecosystem that is difficult to predict and control. While immunotherapies, such as immune checkpoint inhibitors (ICIs), have shown promising results, the TME remains a major barrier to long-term efficacy due to its immunosuppressive nature and therapy-induced adaptations.
Therefore, innovative research is needed to unravel the complex molecular and cellular landscape of the TME and to identify novel targets to reduce relapse, overcome resistance, and prevent drug-resistant clones.
This Special Issue welcomes reviews and research articles spanning basic science to artificial intelligence approaches aimed at enhancing our understanding of the influence of TME on malignancies and improving therapeutic strategies.
Dr. Rada Amin
Guest Editor
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Keywords
- tumor microenvironment
- cancer progression
- malignancies
- immunotherapy
- therapy resistance
- immune evasion
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