Mechanistic Insights into Transplantation Immunology: Immune Regulation and Tolerance
A Special Issue of Biomedicines (ISSN 2227-9059) belonging to the section "Immunology and Immunotherapy".
Deadline for manuscript submissions: 30 April 2027 | Viewed by 279
Editor
Special Issue Information
Dear Colleagues,
Organ transplantation has transformed the management of end-stage organ failure, yet long-term graft survival remains limited by acute and chronic rejection, immunosuppressive toxicity, infection, malignancy, and the incomplete induction of donor-specific tolerance. These challenges reflect a complex and dynamic interaction among donor alloantigens, antigen-presenting cells, effector and regulatory lymphocytes, innate immune populations, stromal cells, metabolic programs, and tissue-specific microenvironments.
This Special Issue, "Mechanistic Insights into Transplantation Immunology: Immune Regulation and Tolerance", will highlight recent advances in the cellular and molecular mechanisms that determine graft injury, adaptation, and durable immune acceptance. We welcome original research articles, reviews, and perspectives addressing donor-antigen recognition and presentation; T- and B-cell regulation; regulatory CD8+ T-cell populations; dendritic-cell and macrophage biology; immune checkpoints; ischemia–reperfusion injury; immunometabolism; microbiota–immune interactions; extracellular vesicle-mediated communication; and mechanisms of operational tolerance. Studies using single-cell sequencing, spatial omics, high-dimensional cytometry, systems immunology, organoid or animal models, and well-characterized clinical cohorts are particularly encouraged.
The Special Issue also aims to bridge mechanistic discovery and clinical translation. Contributions may examine biomarkers for rejection or tolerance, mechanisms of immunosuppressive drug response and resistance, strategies for immune monitoring, and emerging approaches to minimize systemic immunosuppression while preserving protective immunity. By integrating basic, translational, and clinical perspectives across solid-organ transplantation, this collection seeks to define actionable pathways for individualized immune regulation and improved long-term graft and patient outcomes.
Dr. Xin Hu
Guest Editor
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Keywords
- transplantation immunology
- immune tolerance
- allorecognition
- regulatory CD8+ T cells
- immunometabolism
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