Animal Models for Neurological Disease Research
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".
Deadline for manuscript submissions: 30 November 2025 | Viewed by 34
Special Issue Editor
Special Issue Information
Dear Colleagues,
With advancements in genetic engineering, imaging, and high-throughput sequencing, animal models have become indispensable tools for unraveling the molecular and cellular mechanisms underlying neurological diseases. From transgenic and knockout models to emerging non-traditional organisms, these systems provide critical insights into neurodegenerative disorders, psychiatric conditions, and neurodevelopmental syndromes.
This Special Issue invites original research articles and reviews that explore the development, validation, and application of animal models in neurological disease research. We welcome studies covering the following:
- New and established genetic models (e.g., CRISPR/Cas9-based modifications and transgenic organisms);
- Neurophysiological and behavioral analyses in animal models of disease;
- Single-cell and omics approaches to studying neurodegeneration and brain function;
- Comparative insights from non-mammalian models (e.g., zebrafish, lamprey, Drosophila, and C. elegans);
- Innovative biocomputational approaches for analyzing neurological disease pathways;
- Gene therapy and pharmacological interventions were tested in animal models.
Short communications presenting preliminary but impactful findings will also be considered. This Special Issue aims to provide a comprehensive overview of current progress in translational neurobiology, highlighting how animal models continue to drive innovation in neurological disease research.
We look forward to your contributions.
Dr. Sreeja Sarasamma
Guest Editor
Manuscript Submission Information
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Keywords
- animal models
- neurological diseases
- genetic models
- CRISPR/Cas9
- transgenic organisms
- behavioral analysis
- neurodegeneration
- single-cell approaches
- zebrafish
- lamprey
- biocomputational approaches
- gene therapy
- pharmacological interventions
- translational neurobiology
- disease pathways
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