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Biomedicines
Special Issues
Neurovascular Injury: Mechanisms, Diagnosis, Treatment and Repair
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Neurovascular Injury: Mechanisms, Diagnosis, Treatment and Repair

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Neurobiology and Clinical Neuroscience".

Deadline for manuscript submissions: closed (28 February 2023) | Viewed by 4166

Special Issue Editors

Prof. Dr. Kwok-Tung Lu

E-Mail Website
Guest Editor
School of Life Science, National Taiwan Normal University, Taipei, Taiwan
Interests: traumatic brain injury; neurogenesis; brain edema
Prof. Dr. Yiling Yang

E-Mail Website
Guest Editor
Department of Biotechnology, National Chia-Yi University, Chiayi, Taiwan
Interests: traumatic brain injury; neurogenesis; brain edema

Special Issue Information

Dear Colleagues,

Neurovascular injuries encompass all disorders in which an area of the brain, spinal cord, or peripheral nervous system is temporarily or permanently affected by bleeding or restricted blood flow. These injuries have a high incidence and result in a broad spectrum of pathological conditions, ranging from strokes and traumatic brain injury to senile CNS changes. Aging also induces various neurovascular injury-related diseases, including senile neurodegeneration, normal-pressure hydrocephalus, and age-related macular degeneration or choroidal neovascularization. Furthermore, the repair mechanisms of neurogenesis are critical to recovery after neurovascular injury. This Special Issue intends to review the mechanisms, diagnosis, treatments, and repair of central nervous system and peripheral nervous system diseases involving vascular abnormalities. 

Prof. Dr. Kwok-Tung Lu
Prof. Dr. Yiling Yang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • neurovascular injury
  • stroke
  • traumatic brain injury
  • senile neurodegeneration
  • hydrocephalus
  • macular degeneration
  • choroidal neovascularization
  • neurogenesis
  • brain edema

Published Papers (2 papers)

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Research

15 pages, 1125 KiB  
Article
J-Shaped Relationship of Serum Uric Acid with Unfavorable Short-Term Outcomes among Patients with Acute Ischemic Stroke
by Chih-Yang Liu, Cheng-Lun Hsiao, Pei-Ya Chen, Adam Tsou, I-Shiang Tzeng and Shinn-Kuang Lin
Biomedicines 2022, 10(9), 2185; https://doi.org/10.3390/biomedicines10092185 - 4 Sep 2022
Cited by 3 | Viewed by 1313
Abstract
(1) Background: The role of uric acid in stroke outcomes remains inconclusive. (2) Methods: We retrospectively enrolled 3370 patients with acute ischemic stroke. (3) Results: Uric acid level was higher in men than in women. Univariate analyses revealed that the rates of hyperuricemia [...] Read more.
(1) Background: The role of uric acid in stroke outcomes remains inconclusive. (2) Methods: We retrospectively enrolled 3370 patients with acute ischemic stroke. (3) Results: Uric acid level was higher in men than in women. Univariate analyses revealed that the rates of hyperuricemia were higher in all patients and in women for unfavorable outcomes. For death, the hyperuricemia rates were higher in all patients including men and women, and the uric acid levels were also higher in all patients and in women. A J-shaped curve was observed between uric acid and the discharge-modified Rankin Scale score. Patients within Quartiles 1 (<4.1 mg/dL) and 4 (>6.5 mg/dL) of uric acid had higher rates of unfavorable outcomes and death than patients within Quartiles 2 (4.1–5.1 mg/dL) and 3 (5.1–6.2 mg/dL). Multivariable analyses for unfavorable outcomes revealed that Quartile 1 of uric acid was a significant factor in all patients and in men. In men, a significant factor for death was being in Quartile 1 of uric acid. In women, higher levels of uric acid or hyperuricemia (>6.6 mg/dL) were significant factors for death. (4) Conclusions: Lower uric acid levels are a predictor for unfavorable outcomes and death in men, and higher uric acid levels are a predictor for death in women. Full article
(This article belongs to the Special Issue Neurovascular Injury: Mechanisms, Diagnosis, Treatment and Repair)
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9 pages, 240 KiB  
Article
Ilaprazole and Clopidogrel Resistance in Acute Stroke Patients
by In Hwan Lim, Seung Jae Lee, Byoung-Soo Shin and Hyun Goo Kang
Biomedicines 2022, 10(6), 1366; https://doi.org/10.3390/biomedicines10061366 - 9 Jun 2022
Cited by 7 | Viewed by 1861
Abstract
Clopidogrel, an antiplatelet agent used for secondary prevention of cerebrovascular diseases, is often taken with proton pump inhibitors (PPIs). Generally, the combined use of clopidogrel and PPIs causes adverse drug–drug interactions. VerifyNow is a quick and convenient method to confirm clopidogrel resistance (CR), [...] Read more.
Clopidogrel, an antiplatelet agent used for secondary prevention of cerebrovascular diseases, is often taken with proton pump inhibitors (PPIs). Generally, the combined use of clopidogrel and PPIs causes adverse drug–drug interactions. VerifyNow is a quick and convenient method to confirm clopidogrel resistance (CR), which compromises adequate antithrombotic effects. We aimed to confirm CR, identify its factors, and determine the influence of the combination of ilaprazole and clopidogrel on clopidogrel using VerifyNow. In this retrospective study, we examined patients who were receiving clopidogrel after three months, starting within one week from the onset of cerebral infarction symptoms. Clinical records, imaging records, and diagnostic laboratory results, including P2Y12 reaction units (PRU), were compared and analyzed to check for CR. Additionally, the groups treated with either both ilaprazole and clopidogrel or with medications other than ilaprazole were comparatively analyzed. CR was defined as a PRU ≥240 after clopidogrel for three months. Among factors influencing CR by affecting clopidogrel metabolism, positive statistical correlations with age and alcohol consumption were confirmed. The diagnostic tests revealed a lower glomerular filtration rate and platelet count of the CR-positive group. This finding proved that the combination therapy of ilaprazole and clopidogrel is safe, as it does not interfere with the metabolism of clopidogrel. Full article
(This article belongs to the Special Issue Neurovascular Injury: Mechanisms, Diagnosis, Treatment and Repair)
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