Molecular Biomarkers and More Efficient Therapies for Sepsis—2nd Edition

Dear Colleagues,

Sepsis is a life-threatening condition arising from a dysregulated host response to infection, and it remains a critical global health challenge. Its progression often leads to multiple organ dysfunction and significant morbidity and mortality. The pathophysiology of sepsis involves a complex interplay between immune cells, platelets, and other host systems, which work together to combat pathogens but can also result in severe inflammation and organ damage.

Currently, the clinical diagnosis of sepsis relies on the Sequential Organ Failure Assessment (SOFA) score, which measures the severity of organ failure. However, the identification of molecular biomarkers—released either by the host or the pathogen during infection—has opened new avenues for understanding sepsis progression, enhancing diagnostic accuracy, and guiding the development of more effective therapeutic interventions.

We invite you to contribute original research articles, reviews, or short communications that explore recent advances in molecular biomarkers and their role in defining sepsis severity, improving diagnostic methods, and developing more efficient therapies. Submissions addressing signal transduction mechanisms, inflammatory pathways, pathogen–host interactions, and innovative therapeutic approaches are particularly welcome.

Dr. Wen-Lin Su
Dr. Chih-Hao Shen
Dr. Sheng-Kang Chiu
Dr. Yi-Ting Chen
Guest Editors

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