Genetic Architecture of Dementia
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Neurobiology and Clinical Neuroscience".
Deadline for manuscript submissions: closed (31 October 2023) | Viewed by 4056
Special Issue Editors
Interests: genomics; translational medicine; neurology; neurodegenerative disorders
Interests: neurodegeneration; Parkinson’s disease; Alzheimer’s disease; protein aggregation
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Dementia is considered to be a result of complex interactions between environmental factors and genetic changes. Currently, a lot of interest lies in research looking for genetic predictors of dementia. However, most genomic-related studies are limited to genetic risk factors with poorly understood consequences of genetic variability in clinical phenotype, as well as the undefined causative effect on molecular pathways underlying the disease.
This Special Issue entitled “Genetic Architecture of Dementia” will focus on the understanding of mechanisms involved in the development of different types of dementia seen from a genomic perspective using advanced state of the art methods to analyze genetic variability and gene interactions.
We aim to collect high-quality original articles, commentary, and review articles that focus on the study of genetic pathogenesis of possible key pathways of disease development. We highly encourage the submission of papers that support the results of their genetic research with confirmatory experiments on cell and/or animal models.
Understanding the complex genetic background underlying the development of dementia will make it easier to diagnose the causative disease before the onset of irreversible changes, but it also has the potential to aid the discovery of novel mechanisms for the development of targeted therapy.
Prof. Dr. Fran Borovečki
Prof. Dr. Tiago Fleming Outeiro
Guest Editors
Manuscript Submission Information
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Keywords
- next-generation sequencing
- new gene discovery
- genotype-phenotype correlation
- neurodegenerative diseases
- dementia
- neuroimmunology
- biomarkers
- genomics
- molecular mechanism