Gut Microbial Dysbiosis in Disease Pathogenesis
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Microbiology in Human Health and Disease".
Deadline for manuscript submissions: closed (31 January 2024) | Viewed by 6913
Special Issue Editors
Interests: microbiome; chronic inflammation; nutrition; cancer
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The gut microbiota is considered an invisible organ of the human system due to its multiple functional roles. There is no stable microbial composition, and the normal microbial composition varies between different age groups. This is an adaptive and dynamic system that reflects the health status and can be a potential biomarker in the future. The microbiota plays important role in training the immune system and various metabolic pathways. The overuse of antibiotics, poor diet, and lifestyle are some of the factors that affect the healthy microbial composition leading to microbial dysbiosis.
The role of microbial dysbiosis in causing diseases is clear from the increase in allergic and autoimmune diseases observed in developing countries as seen in developed countries. This is attributed to changes in diet and lifestyle that are considered to affect the microbiota.
With affordable next-generation sequencing, microbiome studies are conducted at small and large scales to explore various human diseases. Many such studies observed microbial dysbiosis in various disease conditions. These studies mostly profiled dysbiosis. Microbiome studies in the future are required to establish the mechanistic role of microbial dysbiosis in various disease pathogenesis.
This special issue invites original research and review articles that expand our knowledge on the role of dysbiosis in disease pathogenesis. The studies conducted in animal models and human subjects will be accepted for submission.
Dr. Pugazhendhi Srinivasan
Dr. Nanda Kumar Navalpur Shanmugam
Guest Editors
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Keywords
- microbiome
- dysbiosis
- pathogenesis
- metabolomics
- probiotics
- fecal microbial transplant
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